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IPR005809 is a Succinate--CoA ligase-like, beta subunit.
<p>This entry represents a group of different enzymes that share a similar catalytic mechanism which involves the phosphorylation by ATP (or GTP) of a specific histidine residue in the active site. These enzymes are:</p> <ul><li>Succinate--CoA ligase (GDP-forming ([ec:6.2.1.4]) [[cite:PUB00005004]] is a mitochondrial enzyme that catalyses the substrate level phosphorylation step of the tricarboxylic acid cycle: the formation of succinyl-CoA from succinate with a concomitant hydrolysis of GTP to GDP and phosphate. This enzyme is a dimer composed of an alpha and a beta subunits;</li> <li>Succinate--CoA ligase (ADP-forming) ([ec:6.2.1.5]) [[cite:PUB00000280]] is a bacterial enzyme that during aerobic metabolism functions in the citric acid cycle, coupling the hydrolysis of succinyl-CoA to the synthesis of ATP. It can also function in the other direction for anabolic purposes. This enzyme is a tetramer composed of two alpha and two beta subunits;</li> <li>Malate--CoA ligase ([ec:6.2.1.9]) (malyl-CoA synthetase) [[cite:PUB00002257]], is a bacterial enzyme that forms malyl-CoA from malate and CoA with the concomitant hydrolysis of ATP to ADP and phosphate. Malate-CoA ligase is composed of two different subunits.</li> <li>ADP-forming sulfoacetate-CoA ligase, subunit SauC and SqwK, that catalyse the CoA- and ATP-dependent conversion of sulfoacetate to sulfoacetyl-CoA and ADP [[cite:PUB00153676], [cite:PUB00153675]].</li></ul>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Tricarboxylic acid cycle | A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Succinyl-CoA ligase beta subunit [Caragana jubata] gi|146215968|gb|ABQ10186.1| | 21 | ||
| – | Succinate--CoA ligase [ADP]-forming] subunit beta; TAIR: AT2G20420.1 ATP citrate lyase (ACL) family protein; Swiss-Prot: sp|O82662|SUCB_ARATH Succinate--CoA ligase [ADP]-forming] subunit beta, mitochondrial; TrEMBL-Plants: tr|A5HIG2|A5HIG2_9FABA Succinate-CoA ligase subunit beta; Found in the gene: LotjaGi5g1v0154600 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR01016 | TIGRFAM | 1 | 50.00 |