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IPR006551

Source: InterPro

Description

IPR006551 is a Polynucleotide 3'-phosphatase.

<p>These proteins catalyse the dephosphorylation of DNA 3'-phosphates. It is believed that this activity is important for the repair of single-strand breaks in DNA caused by radiation or oxidative damage. This region is often [[cite:PUB00009675], [cite:PUB00009676]], but not always linked to a DNA 5'-kinase domain [[cite:PUB00009748], [cite:PUB00009749]]. As is common in this superfamily, DNA 3-phosphatase is magnesium dependent. A difference between this enzyme and other HAD-superfamily phosphatases is in the third conserved catalytic motif which usually contains two conserved aspartate residues believed to be involved in binding the magnesium ion. Here, the second aspartate is usually replaced by an arginine residue which may indicate an interaction with the phosphate backbone of the substrate. Alternatively, there is an additional conserved aspartate downstream of the usual site which may indicate a slightly different fold in this region.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj0g3v0096039.1
– PREDICTED: polynucleotide 3'-phosphatase ZDP-like isoform X1 [Cicer arietinum] gi|502177429|ref|XP_004516081.1|
Domains
20
Lj3g3v0427320.1
– PREDICTED: polynucleotide 3'-phosphatase ZDP-like isoform X1 [Cicer arietinum] gi|502177429|ref|XP_004516081.1|
Domains
20
LotjaGi3g1v0041600.1
– Poly [ADP]-ribose] polymerase; TAIR: AT3G14890.1 phosphoesterase; Swiss-Prot: sp|Q84JE8|ZDP_ARATH Polynucleotide 3'-phosphatase ZDP; TrEMBL-Plants: tr|I3S6I9|I3S6I9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0041600
Domains
22

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 33.33