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IPR036957 is a Zinc finger, PARP-type superfamily.
<p>This entry represents the PARP (poly ADP-ribose polymerase) type zinc finger domain superfamily.</p> <p>PARP, also known as NAD(+) ADP-ribosyltransferase ([ec:2.4.2.30]), is a eukaryotic enzyme that catalyses the covalent attachment of ADP-ribose units from NAD(+) to various nuclear acceptor proteins [[cite:PUB00003624], [cite:PUB00005417]]. This post-translational modification of nuclear proteins is dependent on DNA. It appears to be involved in the regulation of various important cellular processes such as differentiation, proliferation and tumour transformation as well as in the regulation of the molecular events involved in the recovery of the cell from DNA damage. Structurally, NAD(+) ADP-ribosyltransferase consists of three distinct domains: an N-terminal zinc-dependent DNA-binding domain, a central automodification domain and a C-terminal NAD-binding domain. The DNA-binding region contains a pair of PARP-type zinc finger domains which have been shown to bind DNA in a zinc-dependent manner. The PARP-type zinc finger domains seem to bind specifically to single-stranded DNA and to act as a DNA nick sensor. DNA ligase III [[cite:PUB00003699]] contains, in its N-terminal section, a single copy of a zinc finger highly similar to those of PARP.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Molecular function | Zinc ion binding | Interacting selectively and non-covalently with zinc (Zn) ions. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Poly [ADP]-ribose] polymerase; TAIR: AT2G31320.1 poly(ADP-ribose) polymerase 2; Swiss-Prot: sp|Q9ZP54|PARP1_ARATH Poly [ADP]-ribose] polymerase 1; TrEMBL-Plants: tr|A0A072U2F3|A0A072U2F3_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi1g1v0711100 | 46 | ||
| – | Poly [ADP]-ribose] polymerase; TAIR: AT2G31320.1 poly(ADP-ribose) polymerase 2; Swiss-Prot: sp|Q9ZP54|PARP1_ARATH Poly [ADP]-ribose] polymerase 1; TrEMBL-Plants: tr|A0A072U2F3|A0A072U2F3_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi1g1v0711100 | 45 | ||
| – | Poly [ADP]-ribose] polymerase; TAIR: AT2G31320.1 poly(ADP-ribose) polymerase 2; Swiss-Prot: sp|Q9ZP54|PARP1_ARATH Poly [ADP]-ribose] polymerase 1; TrEMBL-Plants: tr|A0A072U2F3|A0A072U2F3_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi1g1v0711100 | 45 | ||
| – | Poly [ADP]-ribose] polymerase; TAIR: AT2G31320.1 poly(ADP-ribose) polymerase 2; Swiss-Prot: sp|Q9ZP54|PARP1_ARATH Poly [ADP]-ribose] polymerase 1; TrEMBL-Plants: tr|A0A072U2F3|A0A072U2F3_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi2g1v0337700 | 45 | ||
| – | Poly [ADP]-ribose] polymerase; TAIR: AT2G31320.1 poly(ADP-ribose) polymerase 2; Swiss-Prot: sp|Q9ZP54|PARP1_ARATH Poly [ADP]-ribose] polymerase 1; TrEMBL-Plants: tr|A0A072U2F3|A0A072U2F3_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi2g1v0337700 | 40 | ||
| – | Poly [ADP]-ribose] polymerase; TAIR: AT3G14890.1 phosphoesterase; Swiss-Prot: sp|Q84JE8|ZDP_ARATH Polynucleotide 3'-phosphatase ZDP; TrEMBL-Plants: tr|I3S6I9|I3S6I9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0041600 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |