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IPR006560 is a AWS domain.
<p>This domain, Associated With SET (AWS), whose specific function is still unknown, is found in a group of histone-lysine N-methyltransferases and similar eukaryotic proteins, including Histone-lysine N-methyltransferase, H3 lysine-36 specific from humans (H3-K36-HMTase or Nsd1). Nsd1 is a transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. Mutations in this protein are associated with several human disorders such as Sotos syndrome [[cite:PUB00055387], [cite:PUB00101938]]. This cysteine-rich domain is often found in association with the SET domain ([interpro:IPR001214]).</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Molecular function | Histone-lysine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | ASH1-like protein [Phaseolus vulgaris] gi|342209884|gb|AEL16989.1| | 14 | ||
| – | PREDICTED: histone-lysine N-methyltransferase ASHH2-like [Glycine max] gi|356507632|ref|XP_003522568.1| | 18 | ||
| – | PREDICTED: histone-lysine N-methyltransferase ASHH2-like [Glycine max] gi|356507632|ref|XP_003522568.1| | 18 | ||
| – | PREDICTED: histone-lysine N-methyltransferase ASHH3-like [Glycine max] gi|356530969|ref|XP_003534051.1| | 17 | ||
| – | PREDICTED: histone-lysine N-methyltransferase ASHR3-like [Glycine max] gi|356514491|ref|XP_003525939.1| | 17 | ||
| – | PREDICTED: histone-lysine N-methyltransferase ASHR3-like, partial [Cucumis sativus] gi|449530608|ref|XP_004172286.1| | 15 | ||
| – | Histone-lysine N-methyltransferase; TAIR: AT1G77300.1 histone-lysine N-methyltransferase; Swiss-Prot: sp|Q2LAE1|ASHH2_ARATH Histone-lysine N-methyltransferase ASHH2; TrEMBL-Plants: tr|A0A0B2SJ73|A0A0B2SJ73_GLYSO Histone-lysine N-methyltransferase ASHH2; Found in the gene: LotjaGi1g1v0267000 | 20 | ||
| – | Histone-lysine N-methyltransferase; TAIR: AT1G77300.1 histone-lysine N-methyltransferase; Swiss-Prot: sp|Q2LAE1|ASHH2_ARATH Histone-lysine N-methyltransferase ASHH2; TrEMBL-Plants: tr|A0A0B2SJ73|A0A0B2SJ73_GLYSO Histone-lysine N-methyltransferase ASHH2; Found in the gene: LotjaGi1g1v0267000 | 20 | ||
| – | Histone-lysine N-methyltransferase; TAIR: AT1G77300.1 histone-lysine N-methyltransferase; Swiss-Prot: sp|Q2LAE1|ASHH2_ARATH Histone-lysine N-methyltransferase ASHH2; TrEMBL-Plants: tr|A0A0B2SJ73|A0A0B2SJ73_GLYSO Histone-lysine N-methyltransferase ASHH2; Found in the gene: LotjaGi1g1v0267000 | 20 | ||
| – | Histone-lysine N-methyltransferase; TAIR: AT2G44150.1 histone-lysine N-methyltransferase ASHH3; Swiss-Prot: sp|Q945S8|ASHH3_ARATH Histone-lysine N-methyltransferase ASHH3; TrEMBL-Plants: tr|A0A0B2NX70|A0A0B2NX70_GLYSO Histone-lysine N-methyltransferase ASHH3; Found in the gene: LotjaGi2g1v0165900 | 17 | ||
| – | Histone-lysine N-methyltransferase; TAIR: AT2G44150.1 histone-lysine N-methyltransferase ASHH3; Swiss-Prot: sp|Q945S8|ASHH3_ARATH Histone-lysine N-methyltransferase ASHH3; TrEMBL-Plants: tr|A0A0B2NX70|A0A0B2NX70_GLYSO Histone-lysine N-methyltransferase ASHH3; Found in the gene: LotjaGi2g1v0165900 | 17 | ||
| – | Histone-lysine N-methyltransferase; TAIR: AT1G76710.1 SET domain group 26; Swiss-Prot: sp|Q84WW6|ASHH1_ARATH Histone-lysine N-methyltransferase ASHH1; TrEMBL-Plants: tr|A0A0S3SND2|A0A0S3SND2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0288900 | 15 | ||
| – | Histone-lysine N-methyltransferase; TAIR: AT4G30860.1 SET domain group 4; Swiss-Prot: sp|Q949T8|ASHR3_ARATH Histone-lysine N-methyltransferase ASHR3; TrEMBL-Plants: tr|A0A0L9UBQ6|A0A0L9UBQ6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0199300 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 7.69 |