Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR006676 is a tRNA-splicing endonuclease.
<p>tRNA-splicing endonucleases ([ec:3.1.27.9]) catalyse the endonucleolytic cleavage of pre tRNA at the 5' and 3' splice sites to release the intron and produces two half tRNA molecules bearing 5' hydroxyl and 2', 3'-cyclic phosphate termini [[cite:PUB00054270], [cite:PUB00055529]]. The genes encoding these proteins are homologous in eukaryotes and archea. The eukaryotic tRNA-splicing endonucleases are heterotetrameric while the archaeal endonucleases can be split into homodimeric and homotetrameric subgroups.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | TRNA-intron endonuclease activity | Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. | ||
| Biological process | TRNA splicing, via endonucleolytic cleavage and ligation | Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: tRNA-splicing endonuclease subunit Sen2-1-like [Cicer arietinum] gi|502109005|ref|XP_004493544.1| | 11 | ||
| – | PREDICTED: tRNA-splicing endonuclease subunit Sen2-1-like [Cicer arietinum] gi|502109005|ref|XP_004493544.1| | 6 | ||
| – | TRNA-splicing endonuclease subunit Sen2; TAIR: AT3G45590.1 splicing endonuclease 1; Swiss-Prot: sp|Q9M1E8|SEN21_ARATH tRNA-splicing endonuclease subunit Sen2-1; TrEMBL-Plants: tr|V7CYA6|V7CYA6_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0639100 | 11 | ||
| – | TRNA-splicing endonuclease subunit Sen2; TAIR: AT3G45590.1 splicing endonuclease 1; Swiss-Prot: sp|Q9M1E8|SEN21_ARATH tRNA-splicing endonuclease subunit Sen2-1; TrEMBL-Plants: tr|V7CYA6|V7CYA6_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0723100_LC | 5 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR21227 | PANTHER | 1 | 25.00 |