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IPR006677

Source: InterPro

Description

IPR006677 is a tRNA intron endonuclease, catalytic domain-like.

<p>This entry represents a three-layer α/β/α domain found as the catalytic domain at the C-terminal in homotetrameric tRNA-intron endonucleases [[cite:PUB00020493]], and as domains 2 and 4 (C-terminal) in the homodimeric enzymes [[cite:PUB00041082]]. tRNA-intron endonucleases ([ec:3.1.27.9]) remove tRNA introns by cleaving pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-hydroxyl termini [[cite:PUB00005788]]. These enzymes recognise a pseudosymmetric substrate in which two bulged loops of three bases are separated by a stem of four bp [[cite:PUB00030470]]. Although homotetrameric enzymes contain four active sites, only two participate in the cleavage, and should therefore, be considered as a dimer of dimers.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000213
Molecular function TRNA-intron endonuclease activity Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
Subterm of
GO:0006388
Biological process TRNA splicing, via endonucleolytic cleavage and ligation Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj1g3v3948040.1
– PREDICTED: tRNA-splicing endonuclease subunit Sen2-1-like [Cicer arietinum] gi|502109005|ref|XP_004493544.1|
Domains
11
LotjaGi1g1v0639100.1
– TRNA-splicing endonuclease subunit Sen2; TAIR: AT3G45590.1 splicing endonuclease 1; Swiss-Prot: sp|Q9M1E8|SEN21_ARATH tRNA-splicing endonuclease subunit Sen2-1; TrEMBL-Plants: tr|V7CYA6|V7CYA6_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0639100
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00