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IPR006861 is a Hyaluronan/mRNA-binding protein.
<p>This entry represents a domain found in the HABP4 protein family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role<i>in vivo</i>. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan [[cite:PUB00008623]]. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability [[cite:PUB00008624]]. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.</p> <p>Hyaluronan/mRNA-binding protein may be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription [[cite:PUB00053771], [cite:PUB00053772]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: plasminogen activator inhibitor 1 RNA-binding protein-like [Cicer arietinum] gi|502173509|ref|XP_004515346.1| | 9 | ||
| – | PREDICTED: plasminogen activator inhibitor 1 RNA-binding protein-like [Cicer arietinum] gi|502173509|ref|XP_004515346.1| | 6 | ||
| – | PREDICTED: plasminogen activator inhibitor 1 RNA-binding protein-like [Cicer arietinum] gi|502173509|ref|XP_004515346.1| | 6 | ||
| – | RNA binding protein, putative; TAIR: AT4G17520.1 Hyaluronan / mRNA binding family; Swiss-Prot: sp|O23593|RGGB_ARATH RGG repeats nuclear RNA binding protein B; TrEMBL-Plants: tr|I3STC5|I3STC5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0495200 | 10 | ||
| – | RNA binding protein; TAIR: AT5G47210.1 Hyaluronan / mRNA binding family; Swiss-Prot: sp|Q9LVT8|RGGC_ARATH RGG repeats nuclear RNA binding protein C; TrEMBL-Plants: tr|A0A1J7HKP6|A0A1J7HKP6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0330700_LC | 6 | ||
| – | RNA binding protein, putative; TAIR: AT4G16830.1 Hyaluronan / mRNA binding family; Swiss-Prot: sp|O23523|RGGA_ARATH RGG repeats nuclear RNA binding protein A; TrEMBL-Plants: tr|Q2PEQ5|Q2PEQ5_TRIPR Putative uncharacterized protein; Found in the gene: LotjaGi2g1v0330700_LC | 8 | ||
| – | RNA binding protein; TAIR: AT5G47210.1 Hyaluronan / mRNA binding family; Swiss-Prot: sp|Q9LVT8|RGGC_ARATH RGG repeats nuclear RNA binding protein C; TrEMBL-Plants: tr|A0A1J7HKP6|A0A1J7HKP6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0330700_LC | 6 | ||
| – | RNA binding protein, putative; TAIR: AT4G17520.1 Hyaluronan / mRNA binding family; Swiss-Prot: sp|O23593|RGGB_ARATH RGG repeats nuclear RNA binding protein B; TrEMBL-Plants: tr|A0A1J7GE57|A0A1J7GE57_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0067700 | 10 | ||
| – | RNA binding protein, putative; TAIR: AT4G17520.1 Hyaluronan / mRNA binding family; Swiss-Prot: sp|O23593|RGGB_ARATH RGG repeats nuclear RNA binding protein B; TrEMBL-Plants: tr|A0A1J7H3A4|A0A1J7H3A4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0403600_LC | 7 | ||
| – | RNA binding protein, putative; TAIR: AT4G17520.1 Hyaluronan / mRNA binding family; Swiss-Prot: sp|O23593|RGGB_ARATH RGG repeats nuclear RNA binding protein B; TrEMBL-Plants: tr|Q2PEQ5|Q2PEQ5_TRIPR Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0403600_LC | 7 | ||
| – | RNA binding protein, putative; TAIR: AT4G17520.1 Hyaluronan / mRNA binding family; Swiss-Prot: sp|O23593|RGGB_ARATH RGG repeats nuclear RNA binding protein B; TrEMBL-Plants: tr|A0A1J7H3A4|A0A1J7H3A4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0403600_LC | 7 | ||
| – | RNA binding protein, putative; TAIR: AT4G17520.1 Hyaluronan / mRNA binding family; Swiss-Prot: sp|O23593|RGGB_ARATH RGG repeats nuclear RNA binding protein B; TrEMBL-Plants: tr|A0A1J7H3A4|A0A1J7H3A4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0403600_LC | 11 | ||
| – | RNA binding protein, putative; TAIR: AT4G16830.1 Hyaluronan / mRNA binding family; Swiss-Prot: sp|O23523|RGGA_ARATH RGG repeats nuclear RNA binding protein A; TrEMBL-Plants: tr|Q2PEQ5|Q2PEQ5_TRIPR Putative uncharacterized protein; Found in the gene: LotjaGi5g1v0009500_LC | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 7.69 |