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IPR007699 is a SGS domain.
<p>The SGT1-specific (SGS) domain is a module of ~90 amino acids, which was initially identified in eukaryotic Sgt1 proteins [[cite:PUB00018503]]. It was latter also found in calcyclin-binding proteins [[cite:PUB00018505]]. The SGS domain has been shown to bind to proteins of the S100 family, which are thought to function as sensors of calcium ion concentration in the cell [[cite:PUB00018505]].</p> <p>In budding yeasts, Sgt1 is required for both SCF (Skp1p/Cdc53p-Cullin-F-box)-mediated ubiquitination, cyclic AMP pathway activity and kinetochore function [[cite:PUB00096456]]. Its Schizosaccharomyces pombe homologue, Git7, is required for glucose and cyclic AMP signaling, cell wall integrity, and septation [[cite:PUB00096457]]. Its two homologues in Arabidopsis, SGT1a and SGT1b, can complement two yeast temperature-sensitive sgt1 mutant alleles, suggesting that fundamental cellular function(s) of yeast SGT1in SCF-mediated protein ubiquitylation. Moreover, SGT1a and SGT1b can act as cochaperones with HSP90 and HSC70 and function in regulating multiple resistance (R) genes and environmental responses [[cite:PUB00096458], [cite:PUB00018503], [cite:PUB00096463], [cite:PUB00096462]]. The SGS domain of SGT1 is a key determinant of the HSC70-SGT1 association [[cite:PUB00096462]].</p> <p>Calcyclin (S100A6) is a member of the S100A family of calcium binding proteins and appears to play a role in cell proliferation [[cite:PUB00010521]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: protein SGT1 homolog [Cicer arietinum] gi|502159855|ref|XP_004511553.1| | 22 | ||
| – | PREDICTED: protein SGT1 homolog [Cicer arietinum] gi|502159855|ref|XP_004511553.1| | 22 | ||
| – | Calcyclin-binding protein [Medicago truncatula] gi|357475237|ref|XP_003607904.1| | 13 | ||
| – | Protein SGT1; TAIR: AT4G11260.1 phosphatase-like protein; Swiss-Prot: sp|Q9SUT5|SGT1B_ARATH Protein SGT1 homolog B; TrEMBL-Plants: tr|I3SS23|I3SS23_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0138700 | 21 | ||
| – | SGT1; TAIR: AT4G11260.1 phosphatase-like protein; Swiss-Prot: sp|Q9SUT5|SGT1B_ARATH Protein SGT1 homolog B; TrEMBL-Plants: tr|A0A1J7H3E0|A0A1J7H3E0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0436700 | 22 | ||
| – | SGT1; TAIR: AT4G11260.1 phosphatase-like protein; Swiss-Prot: sp|Q9SUT5|SGT1B_ARATH Protein SGT1 homolog B; TrEMBL-Plants: tr|A0A1J7H3E0|A0A1J7H3E0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0436700 | 22 | ||
| – | Calcyclin-binding protein; TAIR: AT1G30070.1 SGS domain-containing protein; Swiss-Prot: sp|Q9CXW3|CYBP_MOUSE Calcyclin-binding protein; TrEMBL-Plants: tr|I3SHE7|I3SHE7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0082300 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06468 | CDD | 1 | 14.29 |