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IPR008145

Source: InterPro

Description

IPR008145 is a Guanylate kinase/L-type calcium channel beta subunit.

<p>This entry represents a domain found in guanylate kinase ([ec:2.7.4.8]) and in L-type calcium channel.</p> <p>Guanylate kinase ([ec:2.7.4.8]) (GK) [[cite:PUB00003284]] catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP. In prokaryotes (such as Escherichia coli), lower eukaryotes (such as yeast) and in vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids. GK has been shown [[cite:PUB00000870], [cite:PUB00001440], [cite:PUB00005396]] to be structurally similar to protein A57R (or SalG2R) from various strains of Vaccinia virus.</p> <p>L-type calcium channnels are formed from different alpha-1 subunit isoforms that determine the pharmacological properties of the channel, since they form the drug binding domain. Other properties, such as gating voltage-dependence, G protein modulation and kinase susceptibility, are influenced by alpha-2, delta and beta subunits.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 8

Transcript Name Description Predicted domains Domain count
Lj1g3v4274410.1
– Guanylate kinase [Medicago truncatula] gi|357509727|ref|XP_003625152.1|
Domains
17
Lj5g3v0890630.1
– PREDICTED: guanylate kinase-like [Glycine max] gi|356504801|ref|XP_003521183.1|
Domains
20
Lj6g3v1887740.1
– PREDICTED: guanylate kinase-like isoform X1 [Cicer arietinum] gi|502078966|ref|XP_004486110.1|
Domains
16
LotjaGi0g1v0000200.1
– Guanylate kinase; TAIR: AT3G57550.1 guanylate kinase; Swiss-Prot: sp|Q9M682|GMK2_ARATH Guanylate kinase 2; TrEMBL-Plants: tr|A0A0B2P9S7|A0A0B2P9S7_GLYSO Guanylate kinase; Found in the gene: LotjaGi0g1v0000200
Domains
20
LotjaGi0g1v0000200.2
– Guanylate kinase; TAIR: AT3G57550.1 guanylate kinase; Swiss-Prot: sp|Q9M682|GMK2_ARATH Guanylate kinase 2; TrEMBL-Plants: tr|A0A0B2P9S7|A0A0B2P9S7_GLYSO Guanylate kinase; Found in the gene: LotjaGi0g1v0000200
Domains
20
LotjaGi1g1v0720600.1
– Guanylate kinase-like protein; TAIR: AT3G57550.1 guanylate kinase; Swiss-Prot: sp|Q9M682|GMK2_ARATH Guanylate kinase 2; TrEMBL-Plants: tr|A2Q3K9|A2Q3K9_MEDTR Guanylate kinase-like protein; Found in the gene: LotjaGi1g1v0720600
Domains
18
LotjaGi1g1v0720600.2
– Guanylate kinase-like protein; TAIR: AT3G57550.1 guanylate kinase; Swiss-Prot: sp|Q9M682|GMK2_ARATH Guanylate kinase 2; TrEMBL-Plants: tr|A2Q3K9|A2Q3K9_MEDTR Guanylate kinase-like protein; Found in the gene: LotjaGi1g1v0720600
Domains
18
LotjaGi6g1v0300300.1
– Guanylate kinase; TAIR: AT3G06200.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q10M74|GMK2_ORYSJ Guanylate kinase 2, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A0L9VEL3|A0A0L9VEL3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0300300
Domains
16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd00071 CDD 1 12.50