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IPR008384 is a Actin-related protein 2/3 complex subunit 4.
<p>Arp2/3 binds to pre-existing actin filaments and nucleates new daughter filaments, and thus becomes incorporated into the dynamic actin network at the leading edge of motile cells and other actin-based protrusive structures [[cite:PUB00035127]]. In order to nucleate filaments, Arp2/3 must bind to a member of the N-WASp/SCAR family protein [[cite:PUB00020552]]. Arp2 and Arp3 are thought to be brought together after activation, forming an actin-like nucleus for actin monomers to bind and create a new actin filament. In the absence of an activating protein, Arp2/3 shows very little nucleation activity. Recent research has focused on the binding and hydrolysis of ATP by Arp2 and Arp3 [[cite:PUB00035128]], and crystal structures of the Arp2/3 complex have been solved [[cite:PUB00022758]].</p> <p>The human complex consists of Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. This family represents the ARPC4/p20-ARC subunit.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Arp2/3 protein complex | A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. | ||
| Cellular component | Actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. | ||
| Biological process | Actin filament polymerization | Assembly of actin filaments by the addition of actin monomers to a filament. | ||
| Biological process | Arp2/3 complex-mediated actin nucleation | The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Actin-related protein 2/3 complex subunit [Medicago truncatula] gi|357518763|ref|XP_003629670.1| | 6 | ||
| – | Actin-related protein 2/3 complex subunit 4; TAIR: AT4G14147.1 binding protein; Swiss-Prot: sp|F4JUL9|ARPC4_ARATH Actin-related protein 2/3 complex subunit 4; TrEMBL-Plants: tr|G7LHV2|G7LHV2_MEDTR Actin-related protein 2/3 complex subunit 4; Found in the gene: LotjaGi4g1v0373000 | 7 | ||
| – | Actin-related protein 2/3 complex subunit 4; TAIR: AT4G14147.1 binding protein; Swiss-Prot: sp|F4JUL9|ARPC4_ARATH Actin-related protein 2/3 complex subunit 4; TrEMBL-Plants: tr|A0A151TL49|A0A151TL49_CAJCA Actin-related protein 2/3 complex subunit 4; Found in the gene: LotjaGi4g1v0373000 | 7 | ||
| – | Actin-related protein 2/3 complex subunit 4; TAIR: AT4G14147.1 binding protein; Swiss-Prot: sp|F4JUL9|ARPC4_ARATH Actin-related protein 2/3 complex subunit 4; TrEMBL-Plants: tr|A0A061EK66|A0A061EK66_THECC Actin-related protein 2/3 complex subunit 4; Found in the gene: LotjaGi4g1v0373000 | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF69645 | SUPERFAMILY | 1 | 25.00 |