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IPR008434

Source: InterPro

Description

IPR008434 is a Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase.

<p>This family represents the oxidative cyclase responsible for forming the distinctive E-ring of the chlorin ring system under aerobic conditions [[cite:PUB00011279]]. This enzyme is believed to utilise a binuclear iron centre and molecular oxygen. There are two isoforms of this enzyme in some plants and cyanobacteria, which are differentially regulated based on the levels of copper and oxygen [[cite:PUB00015567], [cite:PUB00015568]]. This step is essential in the biosynthesis of both bacteriochlorophyll and chlorophyll under aerobic conditions (a separate enzyme, BchE, acts under anaerobic conditions). This enzyme is found in plants, cyanobacteria and other photosynthetic bacteria.</p> <p>CRD1 (AcsF) is required for the maintenance of photosystem I and its associated light-harvesting complexes in copper-deficient (-Cu) and oxygen-deficient (-O(2)) Chlamydomonas reinhardtii cells and is localised to the thylakoid membrane. The family also contains the Rhodocyclus gelatinosus (Rhodopseudomonas gelatinosa or Rubrivivax gelatinosus) AcsF protein, which codes for a conserved, putative binuclear iron-cluster-containing protein involved in aerobic oxidative cyclization of Mg-protoporphyrin IX monomethyl ester. AcsF and homologs have a leucine zipper and two copies of the conserved glutamate and histidine residues predicted to act as ligands for iron in the Ex(29-35)DExRH motifs. Several homologs of AcsF are found in a wide range of photosynthetic organisms, including Chlamydomonas reinhardtii Crd1 and Pharbitis nil PNZIP, suggesting that this aerobic oxidative cyclization mechanism is conserved from bacteria to plants [[cite:PUB00011279]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0015979
Biological process Photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds.
Subterm of
GO:0015995
Biological process Chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors.
Subterm of
GO:0046872
Molecular function Metal ion binding Interacting selectively and non-covalently with any metal ion.
Subterm of
GO:0048529
Molecular function Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity Catalysis of the reaction: magnesium protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj1g3v4058630.1
– Magnesium-protoporphyrin IX monomethyl ester [oxidative] gi|255565372|ref|XP_002523677.1|
Domains
11
LotjaGi1g1v0654900.1
– Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase; TAIR: AT3G56940.1 dicarboxylate diiron protein, putative (Crd1); Swiss-Prot: sp|Q6SJV8|CRD1_GOSHI Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase, chloroplastic; TrEMBL-Plants: tr|I3SCT7|I3SCT7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0654900
Domains
11
LotjaGi1g1v0654900.2
– Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase; TAIR: AT3G56940.1 dicarboxylate diiron protein, putative (Crd1); Swiss-Prot: sp|Q6SJV8|CRD1_GOSHI Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase, chloroplastic; TrEMBL-Plants: tr|I3SCT7|I3SCT7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0654900
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 33.33