Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR008905 is a Eukaryotic translation initiation factor 3 subunit C, N-terminal domain.
<p>The largest of the mammalian translation initiation factors, eIF3, consists of at least eight subunits ranging in mass from 35 to 170kDa. eIF3 binds to the 40 S ribosome in an early step of translation initiation and promotes the binding of methionyl-tRNAi and mRNA [[cite:PUB00005773]]. The N-terminal domain of eukaryotic translation initiation factor 3 subunit C mediates eIF3 binding to eIF1 and eIF5 [[cite:PUB00064784]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. | ||
| Cellular component | Eukaryotic translation initiation factor 3 complex | A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. | ||
| Biological process | Translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. | ||
| Molecular function | Translation initiation factor binding | Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: eukaryotic translation initiation factor 3 subunit C-like [Cicer arietinum] gi|502076739|ref|XP_004485443.1| | 5 | ||
| – | PREDICTED: eukaryotic translation initiation factor 3 subunit C-like [Glycine max] gi|356505465|ref|XP_003521511.1| | 12 | ||
| – | PREDICTED: eukaryotic translation initiation factor 3 subunit C-like [Glycine max] gi|356524672|ref|XP_003530952.1| | 15 | ||
| – | PREDICTED: eukaryotic translation initiation factor 3 subunit C-like [Glycine max] gi|356512984|ref|XP_003525194.1| | 15 | ||
| – | PREDICTED: eukaryotic translation initiation factor 3 subunit C-like [Glycine max] gi|356524672|ref|XP_003530952.1| | 6 | ||
| – | Eukaryotic translation initiation factor 3 subunit C; TAIR: AT3G56150.1 eukaryotic translation initiation factor 3C; Swiss-Prot: sp|Q9XHM1|EIF3C_MEDTR Eukaryotic translation initiation factor 3 subunit C; TrEMBL-Plants: tr|A0A0L9U9H6|A0A0L9U9H6_PHAAN Eukaryotic translation initiation factor 3 subunit C; Found in the gene: LotjaGi1g1v0742700 | 17 | ||
| – | Eukaryotic translation initiation factor 3 subunit C; TAIR: AT3G56150.1 eukaryotic translation initiation factor 3C; Swiss-Prot: sp|Q9XHM1|EIF3C_MEDTR Eukaryotic translation initiation factor 3 subunit C; TrEMBL-Plants: tr|A0A0L9U9H6|A0A0L9U9H6_PHAAN Eukaryotic translation initiation factor 3 subunit C; Found in the gene: LotjaGi1g1v0742700 | 17 | ||
| – | Eukaryotic translation initiation factor 3 subunit C; TAIR: AT3G56150.1 eukaryotic translation initiation factor 3C; Swiss-Prot: sp|Q9XHM1|EIF3C_MEDTR Eukaryotic translation initiation factor 3 subunit C; TrEMBL-Plants: tr|A0A0L9U9H6|A0A0L9U9H6_PHAAN Eukaryotic translation initiation factor 3 subunit C; Found in the gene: LotjaGi5g1v0284500 | 15 | ||
| – | Eukaryotic translation initiation factor 3 subunit C; TAIR: AT3G56150.1 eukaryotic translation initiation factor 3C; Swiss-Prot: sp|Q9XHM1|EIF3C_MEDTR Eukaryotic translation initiation factor 3 subunit C; TrEMBL-Plants: tr|A0A0L9U9H6|A0A0L9U9H6_PHAAN Eukaryotic translation initiation factor 3 subunit C; Found in the gene: LotjaGi5g1v0284500 | 15 | ||
| – | Eukaryotic translation initiation factor 3 subunit C; TAIR: AT3G56150.1 eukaryotic translation initiation factor 3C; Swiss-Prot: sp|Q9XHM1|EIF3C_MEDTR Eukaryotic translation initiation factor 3 subunit C; TrEMBL-Plants: tr|I1JQD9|I1JQD9_SOYBN Eukaryotic translation initiation factor 3 subunit C; Found in the gene: LotjaGi5g1v0284500 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 10.00 |