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IPR009049 is a Argininosuccinate lyase.
<p>Argininosuccinate lyase (ASL or ASAL, [ec:4.3.2.1]) participates in arginine synthesis in all organisms catalysing the reversible breakdown of argininosuccinate to arginine and fumarate. The reaction is also part of the urea cycle [[cite:PUB00031471]]. The crystal structures of ASLs from several species have been studied, in particular the duck delta1 and delta2 eye lens crystallins, which are inactive and active homologues of ASL, respectively [[cite:PUB00026654]]. ASL is a member of the Lyase class I family, these proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. In humans, mutations in ASAL result in the autosomal recessive disorder argininosuccinic aciduria [[cite:PUB00080874]].</p> <p>This entry represents argininosuccinate lyase and includes avian delta crystallins whose biological role is to provide the optically clear cellular protein of the eye lens.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Argininosuccinate lyase activity | Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. | ||
| Biological process | Arginine biosynthetic process via ornithine | The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Argininosuccinate lyase [Medicago truncatula] gi|357465245|ref|XP_003602904.1| | 18 | ||
| – | PREDICTED: argininosuccinate lyase-like [Glycine max] gi|356508027|ref|XP_003522764.1| | 27 | ||
| – | Argininosuccinate lyase; TAIR: AT5G10920.1 L-Aspartase-like family protein; Swiss-Prot: sp|Q9LEU8|ARLY_ARATH Argininosuccinate lyase, chloroplastic; TrEMBL-Plants: tr|I1JV68|I1JV68_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0346000 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |