Description

IPR010033 is a HAD-superfamily phosphatase, subfamily IIIC.

<p>This entry represents the IIIC subfamily of the Haloacid Dehalogenase (HAD) superfamily of aspartate nucleophile hydrolases. Subfamily III, which includes subfamily IIIA ([interpro:IPR006549]) and subfamily IIIB ([interpro:IPR005519]) contains sequences which do not contain either of the insert domains between the 1st and 2nd conserved catalytic motifs, subfamily I ([interpro:IPR006439], [interpro:IPR006545], [interpro:IPR006434], and [interpro:IPR006435]), or between the 2nd and 3rd, subfamily II ([interpro:IPR006357], and [interpro:IPR006379]). Subfamily IIIC contains five relatively distantly related clades: a family of viral proteins ([interpro:IPR007827]), a family of eukaryotic proteins called MDP-1 and a family of archaeal proteins most closely related to MDP-1 ([interpro:IPR010036]), a family of bacteria including the Streptomyces FkbH protein ([interpro:IPR010037]), and a small clade including the Pasteurella multocida BcbF and EcbF proteins. The overall lack of species overlap among these clades may indicate a conserved function, but the degree of divergence between the clades and the differences in architecture outside of the domain in some clades warns against such a conclusion. No member of this subfamily is characterised with respect to function, however the MDP-1 protein [[cite:PUB00009589]] is a characterised phosphatase. All of the characterised enzymes within subfamily III are phosphatases, and all of the active site residues characteristic of HAD-superfamily phosphatases [[cite:PUB00003337]] are present in subfamily IIIC.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 6

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: