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IPR010541 is a Small nuclear ribonucleoprotein Prp3, C-terminal domain.
<p>This domain is found at the C-terminal end of U4/U6 and U4/U5/U6-small nuclear ribonucleoprotein Prp3, part of the tri-RNA complex that form the spliceosome. Prp3 plays a key role in the recognition of the snRNA duplex. Defects in PRPF3 are the cause of retinitis pigmentosa type 18 (RP18). RP leads to degeneration of retinal photoreceptor cells [[cite:PUB00033315], [cite:PUB00062917], [cite:PUB00062918]]. In<i>Arabidposis thaliana</i>, protein RDM16 acts as a pre-mRNA splicing factor and functions in RNA-directed DNA methylation by influencing Pol V transcript levels [[cite:PUB00083217]].</p> <p>This binding domain, highly conserved among eukaryotes, interacts with the 3' end of U6 snRNA. It adopts a ferredoxin-like fold, showing a five-stranded mixed β-sheet with three α-helices, two of them running parallel to the β-strands on one side of the sheet and one on the other. This fold is extended with a long β-hairpin, an extra β-strand, an helix and a final loop at the C terminus [[cite:PUB00100665], [cite:PUB00100667], [cite:PUB00100664], [cite:PUB00100666]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: U4/U6 small nuclear ribonucleoprotein Prp3-like [Glycine max] gi|356495750|ref|XP_003516736.1| | 8 | ||
| – | U4/U6 small nuclear ribonucleoprotein Prp3; TAIR: AT1G28060.1 Pre-mRNA-splicing factor 3; Swiss-Prot: sp|Q9C7E7|RDM16_ARATH Protein RDM16; TrEMBL-Plants: tr|I1JAI8|I1JAI8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0359600 | 8 | ||
| – | U4/U6 small nuclear ribonucleoprotein Prp3; TAIR: AT1G28060.1 Pre-mRNA-splicing factor 3; Swiss-Prot: sp|Q9C7E7|RDM16_ARATH Protein RDM16; TrEMBL-Plants: tr|A0A151SCZ2|A0A151SCZ2_CAJCA U4/U6 small nuclear ribonucleoprotein Prp3; Found in the gene: LotjaGi5g1v0359600 | 8 | ||
| – | U4/U6 small nuclear ribonucleoprotein Prp3; TAIR: AT1G28060.1 Pre-mRNA-splicing factor 3; Swiss-Prot: sp|Q9C7E7|RDM16_ARATH Protein RDM16; TrEMBL-Plants: tr|A0A151SCZ2|A0A151SCZ2_CAJCA U4/U6 small nuclear ribonucleoprotein Prp3; Found in the gene: LotjaGi5g1v0359600 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |