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IPR011256 is a Regulatory factor, effector binding domain superfamily.
<p>The effector domain is found in bacterial transcription factors and other regulatory proteins. The effector domain consists of a duplicated β/α/β motif, where the antiparallel β sheets form a barrel structure. Several proteins contain this domain. For example, the multidrug-binding domain of the transcription factor BmrR, which transcriptionally regulates multidrug transporters [[cite:PUB00014475]]. This domain is also present at the C-terminal domain of the Rob transcription factor, which regulates genes involved in resistance to antibiotics, organic solvents, and heavy metals [[cite:PUB00012391]]. Additionally, the effector domain can be found in the gyrase inhibitory protein GyrI (SbmC, TeeB) that suppresses cell proliferation by inhibiting bacterial gyrase activity [[cite:PUB00014478]].</p> <p>This domain is also found in heme-binding proteins 1-2 (HEBP1-2) and testis-expressed 264 proteins found in eukaryotes.</p> <p>HEBP1-2 are part of the heme-binding protein HBP/SOUL family, which represents a group of evolutionary conserved putative heme-binding proteins. In humans, HEBP1 binds metalloporphyrins, free porphyrins and N-methylprotoporphyrins with similar affinities [[cite:PUB00160396]]. HEBP2, in humans, can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions [[cite:PUB00160397]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Heme-binding-like protein [Medicago truncatula] gi|357450683|ref|XP_003595618.1| | 10 | ||
| – | PREDICTED: heme-binding-like protein At3g10130, chloroplastic-like [Cicer arietinum] gi|502146870|ref|XP_004506644.1| | 5 | ||
| – | Heme-binding-like protein [Medicago truncatula] gi|357469073|ref|XP_003604821.1| | 5 | ||
| – | PREDICTED: heme-binding protein 1-like [Cicer arietinum] gi|502152353|ref|XP_004508887.1| | 12 | ||
| – | PREDICTED: heme-binding protein 2-like [Glycine max] gi|356498208|ref|XP_003517945.1| | 13 | ||
| – | PREDICTED: heme-binding-like protein At3g10130, chloroplastic-like [Glycine max] gi|356572562|ref|XP_003554437.1| | 6 | ||
| – | PREDICTED: heme-binding protein 1-like [Cicer arietinum] gi|502152353|ref|XP_004508887.1| | 13 | ||
| – | Heme-binding protein, putative; TAIR: AT1G17100.1 SOUL heme-binding family protein; Swiss-Prot: sp|Q9Y5Z4|HEBP2_HUMAN Heme-binding protein 2; TrEMBL-Plants: tr|I3T2Y8|I3T2Y8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0178100 | 14 | ||
| – | SOUL heme-binding family protein; TAIR: AT5G20140.1 SOUL heme-binding family protein; Swiss-Prot: sp|Q9SR77|HBPL1_ARATH Heme-binding-like protein At3g10130, chloroplastic; TrEMBL-Plants: tr|A0A0B2Q1X0|A0A0B2Q1X0_GLYSO Heme-binding-like protein, chloroplastic; Found in the gene: LotjaGi1g1v0201400 | 12 | ||
| – | SOUL heme-binding family protein; TAIR: AT5G20140.2 SOUL heme-binding family protein; Swiss-Prot: sp|Q9SR77|HBPL1_ARATH Heme-binding-like protein At3g10130, chloroplastic; TrEMBL-Plants: tr|A0A0R0JK90|A0A0R0JK90_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0201400 | 11 | ||
| – | SOUL heme-binding family protein; TAIR: AT3G10130.1 SOUL heme-binding family protein; Swiss-Prot: sp|Q9SR77|HBPL1_ARATH Heme-binding-like protein At3g10130, chloroplastic; TrEMBL-Plants: tr|A0A151TVP2|A0A151TVP2_CAJCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0675700 | 7 | ||
| – | SOUL heme-binding family protein; TAIR: AT2G37970.1 SOUL heme-binding family protein; Swiss-Prot: sp|Q9SR77|HBPL1_ARATH Heme-binding-like protein At3g10130, chloroplastic; TrEMBL-Plants: tr|G7JRA5|G7JRA5_MEDTR SOUL heme-binding family protein; Found in the gene: LotjaGi3g1v0217700 | 7 | ||
| – | Heme-binding protein, putative; TAIR: AT1G17100.1 SOUL heme-binding family protein; Swiss-Prot: sp|Q6NU05|HEBP1_XENLA Heme-binding protein 1; TrEMBL-Plants: tr|A0A072TS05|A0A072TS05_MEDTR SOUL heme-binding family protein; Found in the gene: LotjaGi4g1v0156500 | 14 | ||
| – | Heme-binding protein, putative; TAIR: AT1G17100.1 SOUL heme-binding family protein; Swiss-Prot: sp|Q9Y5Z4|HEBP2_HUMAN Heme-binding protein 2; TrEMBL-Plants: tr|I3SE15|I3SE15_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0231400 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SignalP-noTM | SignalP_GRAM_NEGATIVE | 1 | 7.14 |