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IPR011641

Description

IPR011641 is a Tyrosine-protein kinase ephrin type A/B receptor-like.

<p>This entry represents a domain found in various ephrin type A and B receptors, which have tyrosine kinase activity.</p> <p>Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [[cite:PUB00005115]]:</p> <ul> <li>Serine/threonine-protein kinases</li> <li>Tyrosine-protein kinases</li> <li>Dual specificity protein kinases (e.g. MEK -phosphorylates both Thr and Tyr on target proteins)</li> </ul> <p>Protein kinase function is evolutionarily conserved from Escherichia coli to human [[cite:PUB00020114]]. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation [[cite:PUB00015362]]. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [[cite:PUB00034898]], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [[cite:PUB00034899]].</p> <p>Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups [[cite:PUB00020114]]:</p> <ul> <li>Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis [[cite:PUB00052410]]. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction [[cite:PUB00052411]].</li> <li>Cytoplasmic/non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [[cite:PUB00052412]].</li> </ul>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 14

Transcript Name Description Predicted domains Domain count
Uncharacterized protein isoform 1 [Theobroma cacao] gi|508782580|gb|EOY29836.1| 8
Uncharacterized protein isoform 1 [Theobroma cacao] gi|508776861|gb|EOY24117.1| 7
Uncharacterized protein isoform 1 [Theobroma cacao] gi|508776861|gb|EOY24117.1| 12
Glycine-rich protein; TAIR: AT5G11700.2 ephrin type-B receptor; Swiss-Prot: sp|P06882|THYG_RAT Thyroglobulin; TrEMBL-Plants: tr|K7KU15|K7KU15_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0410100 14
Glycine-rich protein; TAIR: AT5G11700.2 ephrin type-B receptor; Swiss-Prot: sp|Q641W2|MYG1_RAT UPF0160 protein MYG1, mitochondrial; TrEMBL-Plants: tr|K7KU15|K7KU15_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0410100 14
Glycine-rich protein; TAIR: AT5G11700.2 ephrin type-B receptor; Swiss-Prot: sp|Q58464|Y1064_METJA Uncharacterized acetyltransferase MJ1064; TrEMBL-Plants: tr|K7KU15|K7KU15_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0410100 14
Glycine-rich protein; TAIR: AT5G47020.1 MraZ; Swiss-Prot: sp|Q5H8C4|VP13A_MOUSE Vacuolar protein sorting-associated protein 13A; TrEMBL-Plants: tr|V7CH42|V7CH42_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0417200 13
Glycine-rich protein; TAIR: AT5G47020.1 MraZ; Swiss-Prot: sp|Q5H8C4|VP13A_MOUSE Vacuolar protein sorting-associated protein 13A; TrEMBL-Plants: tr|V7CH42|V7CH42_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0417200 13
Glycine-rich protein; TAIR: AT5G47020.1 MraZ; Swiss-Prot: sp|Q5H8C4|VP13A_MOUSE Vacuolar protein sorting-associated protein 13A; TrEMBL-Plants: tr|V7CH42|V7CH42_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0417200 13
Glycine-rich protein; TAIR: AT5G47020.1 MraZ; Swiss-Prot: sp|Q5H8C4|VP13A_MOUSE Vacuolar protein sorting-associated protein 13A; TrEMBL-Plants: tr|V7CH42|V7CH42_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0417200 13
Glycine-rich protein; TAIR: AT5G47020.1 MraZ; Swiss-Prot: sp|Q5H8C4|VP13A_MOUSE Vacuolar protein sorting-associated protein 13A; TrEMBL-Plants: tr|V7CH42|V7CH42_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0417200 13
Glycine-rich protein; TAIR: AT5G47020.1 MraZ; Swiss-Prot: sp|Q5H8C4|VP13A_MOUSE Vacuolar protein sorting-associated protein 13A; TrEMBL-Plants: tr|V7CH42|V7CH42_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0417200 8
Glycine-rich protein; TAIR: AT5G11700.1 ephrin type-B receptor; Swiss-Prot: sp|Q9KS12|MARTX_VIBCH Multifunctional-autoprocessing repeats-in-toxin; TrEMBL-Plants: tr|K7L4P8|K7L4P8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0443100 9
Glycine-rich protein; TAIR: AT5G11700.1 ephrin type-B receptor; Swiss-Prot: sp|P24756|A53R_VACCW Truncated secreted TNF-receptor-like protein A53R; TrEMBL-Plants: tr|K7L4P8|K7L4P8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0443100 9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 7.14