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IPR012258 is a Acyl-CoA oxidase.
<p>Acyl-CoA oxidase (ACO) acts on CoA derivatives of fatty acids with chain lengths from 8 to 18. It catalyses the first and rate-determining step of the peroxisomal beta-oxidation of fatty acids and a major producer of hydrogen peroxide (H2O2) [[cite:PUB00026133], [cite:PUB00097235]].</p> <p>Acyl-CoA oxidase is a homodimer and the polypeptide chain of the subunit is folded into the N-terminal alpha-domain, beta-domain, and C-terminal alpha-domain [[cite:PUB00026133], [cite:PUB00026133]]. Functional differences between the peroxisomal acyl-CoA oxidases and the mitochondrial acyl-CoA dehydrogenases are attributed to structural differences in the FAD environments [[cite:PUB00032141]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Acyl-CoA oxidase activity | Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide. | ||
| Cellular component | Peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. | ||
| Biological process | Fatty acid metabolic process | The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. | ||
| Molecular function | FAD binding | Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: peroxisomal acyl-coenzyme A oxidase 1-like [Cicer arietinum] gi|502152467|ref|XP_004508938.1| | 18 | ||
| – | PREDICTED: acyl-coenzyme A oxidase 2, peroxisomal-like [Glycine max] gi|356512717|ref|XP_003525063.1| | 16 | ||
| – | Acyl-coenzyme A oxidase; TAIR: AT4G16760.1 acyl-CoA oxidase 1; Swiss-Prot: sp|O65202|ACOX1_ARATH Peroxisomal acyl-coenzyme A oxidase 1; TrEMBL-Plants: tr|G7JXE0|G7JXE0_MEDTR Acyl-coenzyme A oxidase; Found in the gene: LotjaGi2g1v0421200 | 18 | ||
| – | Acyl-coenzyme A oxidase; TAIR: AT4G16760.1 acyl-CoA oxidase 1; Swiss-Prot: sp|O65202|ACOX1_ARATH Peroxisomal acyl-coenzyme A oxidase 1; TrEMBL-Plants: tr|G7JXE0|G7JXE0_MEDTR Acyl-coenzyme A oxidase; Found in the gene: LotjaGi2g1v0421200 | 18 | ||
| – | Acyl-coenzyme A oxidase; TAIR: AT4G16760.1 acyl-CoA oxidase 1; Swiss-Prot: sp|O65202|ACOX1_ARATH Peroxisomal acyl-coenzyme A oxidase 1; TrEMBL-Plants: tr|G7JXE0|G7JXE0_MEDTR Acyl-coenzyme A oxidase; Found in the gene: LotjaGi2g1v0421200 | 18 | ||
| – | Acyl-coenzyme A oxidase; TAIR: AT1G06290.1 acyl-CoA oxidase 3; Swiss-Prot: sp|P0CZ23|ACOX3_ARATH Acyl-coenzyme A oxidase 3, peroxisomal; TrEMBL-Plants: tr|G7JUZ2|G7JUZ2_MEDTR Acyl-coenzyme A oxidase; Found in the gene: LotjaGi3g1v0244500 | 16 | ||
| – | Acyl-coenzyme A oxidase; TAIR: AT1G06290.1 acyl-CoA oxidase 3; Swiss-Prot: sp|P0CZ23|ACOX3_ARATH Acyl-coenzyme A oxidase 3, peroxisomal; TrEMBL-Plants: tr|G7JUZ2|G7JUZ2_MEDTR Acyl-coenzyme A oxidase; Found in the gene: LotjaGi3g1v0244600 | 16 | ||
| – | Acyl-coenzyme A oxidase; TAIR: AT4G16760.1 acyl-CoA oxidase 1; Swiss-Prot: sp|O65202|ACOX1_ARATH Peroxisomal acyl-coenzyme A oxidase 1; TrEMBL-Plants: tr|Q945U3|Q945U3_SOYBN Acyl-coenzyme A oxidase; Found in the gene: LotjaGi4g1v0200600 | 18 | ||
| – | Acyl-coenzyme A oxidase; TAIR: AT5G65110.1 acyl-CoA oxidase 2; Swiss-Prot: sp|O65201|ACOX2_ARATH Acyl-coenzyme A oxidase 2, peroxisomal; TrEMBL-Plants: tr|A0A151RRP6|A0A151RRP6_CAJCA Acyl-coenzyme A oxidase; Found in the gene: LotjaGi4g1v0399400 | 18 | ||
| – | Acyl-coenzyme A oxidase; TAIR: AT5G65110.1 acyl-CoA oxidase 2; Swiss-Prot: sp|O65201|ACOX2_ARATH Acyl-coenzyme A oxidase 2, peroxisomal; TrEMBL-Plants: tr|A0A151RRP6|A0A151RRP6_CAJCA Acyl-coenzyme A oxidase; Found in the gene: LotjaGi4g1v0399400 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01150 | CDD | 1 | 10.00 |