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IPR012319

Source: InterPro

Description

IPR012319 is a Formamidopyrimidine-DNA glycosylase, catalytic domain.

<p>This entry represents the catalytic domain of DNA glycosylase/AP lyase enzymes, which are involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Most damage to bases in DNA is repaired by the base excision repair pathway [[cite:PUB00018046]]. These enzymes are primarily from bacteria, and have both DNA glycosylase activity ([ec:3.2.2]) and AP lyase activity ([ec:4.2.99.18]). Examples include formamidopyrimidine-DNA glycosylases (Fpg; MutM) and endonuclease VIII (Nei).</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003684
Molecular function Damaged DNA binding Interacting selectively and non-covalently with damaged DNA.
Subterm of
GO:0003906
Molecular function DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).
Subterm of
GO:0006284
Biological process Base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
Subterm of
GO:0008270
Molecular function Zinc ion binding Interacting selectively and non-covalently with zinc (Zn) ions.
Subterm of
GO:0016799
Molecular function Hydrolase activity, hydrolyzing N-glycosyl compounds Catalysis of the hydrolysis of any N-glycosyl bond.
Subterm of

Associated Lotus transcripts 5

Transcript Name Description Predicted domains Domain count
Lj3g3v0044230.1
– PREDICTED: formamidopyrimidine-DNA glycosylase-like isoform X2 [Cicer arietinum] gi|502080701|ref|XP_004486650.1|
Domains
18
Lj3g3v0044230.2
– PREDICTED: formamidopyrimidine-DNA glycosylase-like isoform X1 [Cicer arietinum] gi|502080698|ref|XP_004486649.1|
Domains
18
LotjaGi3g1v0007500.1
– Formamidopyrimidine-DNA glycosylase; TAIR: AT1G52500.2 MUTM homolog-1; Swiss-Prot: sp|O80358|FPG_ARATH Formamidopyrimidine-DNA glycosylase; TrEMBL-Plants: tr|A0A151SPP2|A0A151SPP2_CAJCA Formamidopyrimidine-DNA glycosylase; Found in the gene: LotjaGi3g1v0007500
Domains
19
LotjaGi3g1v0007500.2
– Formamidopyrimidine-DNA glycosylase; TAIR: AT1G52500.2 MUTM homolog-1; Swiss-Prot: sp|O80358|FPG_ARATH Formamidopyrimidine-DNA glycosylase; TrEMBL-Plants: tr|G7II90|G7II90_MEDTR Formamidopyrimidine-DNA glycosylase; Found in the gene: LotjaGi3g1v0007500
Domains
19
LotjaGi3g1v0007500.3
– Formamidopyrimidine-DNA glycosylase; TAIR: AT1G52500.1 MUTM homolog-1; Swiss-Prot: sp|O80358|FPG_ARATH Formamidopyrimidine-DNA glycosylase; TrEMBL-Plants: tr|A0A151SPP2|A0A151SPP2_CAJCA Formamidopyrimidine-DNA glycosylase; Found in the gene: LotjaGi3g1v0007500
Domains
18

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd08972 CDD 1 20.00