Description

IPR013657 is a SLC35B1-4/HUT1.

<p>This family represents a group of nucleotide sugar transporters (NSTs) that belong to the SLC35 family of solute carriers and their function is highly conserved from simple eukaryotes, fungi and parasites to plants and mammals, including the nucleotide sugar transporters SLC35B1-4 from human and HUT1 and YEA4 from yeast [[cite:PUB00020858], [cite:PUB00103680], [cite:PUB00103681], [cite:PUB00103679]]. Members of this family localize at the Golgi apparatus and/or the endoplasmic reticulum (ER) and exhibit different substrate specificities, for instance, YEA4 has specificity for UDP-N-acetylglucosamine, which is localized in the ER and required for chitin synthesis [[cite:PUB00103678]]. SLC35B1 from human has been identified as a ATP:ADP antiporter that catalyses the exchange of ATP and ADP across the ER membrane where it imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction. SLC35B1 regulates ER energy metabolism, probably as part of a calcium-dependent ER to cytosol low energy response axis and it also provides ATP to ER chaperones required for proper protein folding and trafficking in the ER [[cite:PUB00103683], [cite:PUB00103682]]. HUT1, SLC35B1 orthologues, play a more general role in ER homeostasis [[cite:PUB00103684], [cite:PUB00070623]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 22

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: