Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR013791 is a RNA 3'-terminal phosphate cyclase, insert domain.
<p>RNA cyclases are a family of RNA-modifying enzymes that are conserved in eukaryotes, bacteria and archaea. RNA 3'-terminal phosphate cyclase ([ec:6.5.1.4]) [[cite:PUB00001300], [cite:PUB00003565]] catalyses the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA.</p> <reaction> ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate </reaction> <p>These enzymes might be responsible for production of the cyclic phosphate RNA ends that are known to be required by many RNA ligases in both prokaryotes and eukaryotes.</p> <p>RNA cyclase is a protein of from 36 to 42kDa. The best conserved region is a glycine-rich stretch of residues located in the central part of the sequence and which is reminiscent of various ATP, GTP or AMP glycine-rich loops.</p> <p>The crystal structure of RNA 3'-terminal phosphate cyclase shows that each molecule consists of two domains. The larger domain contains three repeats of a folding unit comprising two parallel α helices and a four-stranded β sheet; this fold was previously identified in translation initiation factor 3 (IF3). The large domain is similar to one of the two domains of 5-enolpyruvylshikimate-3-phosphate synthase and UDP-N-acetylglucosamine enolpyruvyl transferase. The smaller insert domain disrupts the large domain, and uses a similar secondary structure element with different topology, observed in many other proteins such as thioredoxin [[cite:PUB00006476]]. Although the active site of this enzyme could not be unambiguously assigned, it can be mapped to a region surrounding His309, an adenylate acceptor, in which a number of amino acids are highly conserved in the enzyme from different sources [[cite:PUB00006476]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: LOW QUALITY PROTEIN: probable RNA 3'-terminal phosphate cyclase-like protein-like [Glycine max] gi|356496398|ref|XP_003517055.1| | 20 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: probable RNA 3'-terminal phosphate cyclase-like protein-like [Glycine max] gi|356496398|ref|XP_003517055.1| | 21 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: probable RNA 3'-terminal phosphate cyclase-like protein-like [Glycine max] gi|356496398|ref|XP_003517055.1| | 21 | ||
| – | RNA 3-terminal phosphate cyclase-like protein, putative; TAIR: AT5G22100.1 RNA cyclase family protein; Swiss-Prot: sp|Q9C578|RCL1_ARATH Probable RNA 3'-terminal phosphate cyclase-like protein; TrEMBL-Plants: tr|A0A151S8V9|A0A151S8V9_CAJCA Putative RNA 3'-terminal phosphate cyclase-like protein; Found in the gene: LotjaGi2g1v0126600 | 23 | ||
| – | RNA 3-terminal phosphate cyclase-like protein, putative; TAIR: AT5G22100.1 RNA cyclase family protein; Swiss-Prot: sp|Q9C578|RCL1_ARATH Probable RNA 3'-terminal phosphate cyclase-like protein; TrEMBL-Plants: tr|A0A151S8V9|A0A151S8V9_CAJCA Putative RNA 3'-terminal phosphate cyclase-like protein; Found in the gene: LotjaGi2g1v0126600 | 23 | ||
| – | RNA 3-terminal phosphate cyclase-like protein, putative; TAIR: AT5G22100.1 RNA cyclase family protein; Swiss-Prot: sp|Q9C578|RCL1_ARATH Probable RNA 3'-terminal phosphate cyclase-like protein; TrEMBL-Plants: tr|A0A151S8V9|A0A151S8V9_CAJCA Putative RNA 3'-terminal phosphate cyclase-like protein; Found in the gene: LotjaGi2g1v0126600 | 17 | ||
| – | RNA 3-terminal phosphate cyclase-like protein, putative; TAIR: AT5G22100.1 RNA cyclase family protein; Swiss-Prot: sp|Q9C578|RCL1_ARATH Probable RNA 3'-terminal phosphate cyclase-like protein; TrEMBL-Plants: tr|A0A151S8V9|A0A151S8V9_CAJCA Putative RNA 3'-terminal phosphate cyclase-like protein; Found in the gene: LotjaGi2g1v0126600 | 23 | ||
| – | RNA 3-terminal phosphate cyclase-like protein, putative; TAIR: AT5G22100.1 RNA cyclase family protein; Swiss-Prot: sp|Q9C578|RCL1_ARATH Probable RNA 3'-terminal phosphate cyclase-like protein; TrEMBL-Plants: tr|A0A151S8V9|A0A151S8V9_CAJCA Putative RNA 3'-terminal phosphate cyclase-like protein; Found in the gene: LotjaGi2g1v0193200 | 23 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00875 | CDD | 1 | 12.50 |