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IPR014039 is a Translation elongation factor EFTs/EF1B, dimerisation.
<p>Translation elongation factors are responsible for two main processes during protein synthesis on the ribosome [[cite:PUB00033953], [cite:PUB00033952], [cite:PUB00033951]]. EF1A (or EF-Tu) is responsible for the selection and binding of the cognate aminoacyl-tRNA to the A-site (acceptor site) of the ribosome. EF2 (or EF-G) is responsible for the translocation of the peptidyl-tRNA from the A-site to the P-site (peptidyl-tRNA site) of the ribosome, thereby freeing the A-site for the next aminoacyl-tRNA to bind. Elongation factors are responsible for achieving accuracy of translation and both EF1A and EF2 are remarkably conserved throughout evolution.</p> <p>Elongation factor EF1B (also known as EF-Ts or EF-1beta/gamma/delta) is a nucleotide exchange factor that is required to regenerate EF1A from its inactive form (EF1A-GDP) to its active form (EF1A-GTP). EF1A is then ready to interact with a new aminoacyl-tRNA to begin the cycle again. EF1B is more complex in eukaryotes than in bacteria, and can consist of three subunits: EF1B-alpha (or EF-1beta), EF1B-gamma (or EF-1gamma) and EF1B-beta (or EF-1delta) [[cite:PUB00033953]].</p> <p>This entry represents the C-terminal dimerisation domain found primarily in EF-Tu (EF1A) proteins from bacteria, mitochondria and chloroplasts.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Translation elongation factor activity | Functions in chain elongation during polypeptide synthesis at the ribosome. | ||
| Biological process | Translational elongation | The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: enolase-phosphatase E1-like isoform X1 [Cicer arietinum] gi|502163996|ref|XP_004513014.1| | 27 | ||
| – | PREDICTED: elongation factor Ts, mitochondrial-like [Cicer arietinum] gi|502090285|ref|XP_004489179.1| | 16 | ||
| – | Elongation factor Ts; TAIR: AT4G29060.1 elongation factor Ts family protein; Swiss-Prot: sp|B7K735|EFTS_CYAP7 Elongation factor Ts; TrEMBL-Plants: tr|A0A0B2SMD5|A0A0B2SMD5_GLYSO Elongation factor Ts, mitochondrial; Found in the gene: LotjaGi2g1v0220500 | 28 | ||
| – | Elongation factor Ts; TAIR: AT4G11120.1 translation elongation factor Ts (EF-Ts); Swiss-Prot: sp|B9SEZ6|EFTS_RICCO Elongation factor Ts, mitochondrial; TrEMBL-Plants: tr|A0A1J7GW85|A0A1J7GW85_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0237800 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd14275 | CDD | 1 | 25.00 |