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IPR015699

Source: InterPro

Description

IPR015699 is a DNA-directed RNA pol I, largest subunit, N-terminal domain.

<p>This entry represents the N-terminal domain of the largest subunit of DNA-directed RNA polymerase I, also known as subunit RPA1, which constitutes the catalytic core component of RNA Pol I [[cite:PUB00076664]]. The yeast member of this family is known as Rpb190 [[cite:PUB00091472]]. This domain forms part of the active site.</p> <p>DNA-dependent RNA polymerases ([ec:2.7.7.6]) are responsible for the polymerisation of ribonucleotides into a sequence complementary to the template DNA. In eukaryotes, there are three different forms of DNA-dependent RNA polymerases transcribing different sets of genes. Most RNA polymerases are multimeric enzymes and are composed of a variable number of subunits. RNA synthesis follows after the attachment of RNA polymerase to a specific site, the promoter, on the template DNA strand. The RNA synthesis process continues until a termination sequence is reached. The RNA product, which is synthesised in the 5' to 3' direction, is known as the primary transcript.</p> <p>Eukaryotic nuclei contain three distinct types of RNA polymerases that differ in the RNA they synthesise:</p> <p>1. RNA polymerase I: located in the nucleoli, synthesises precursors of most ribosomal RNAs.</p> <p>2. RNA polymerase II: occurs in the nucleoplasm, synthesises mRNA precursors.</p> <p>3. RNA polymerase III: also occurs in the nucleoplasm, synthesises the precursors of 5S ribosomal RNA, the tRNAs, and a variety of other small nuclear and cytosolic RNAs.</p> <p>Eukaryotic cells are also known to contain separate mitochondrial and chloroplast RNA polymerases. Eukaryotic RNA polymerases, whose molecular masses vary in size from 500 to 700kDa, contain two non-identical large (greater than 100kDa) subunits and an array of up to 12 different small (less than 50kDa) subunits.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003899
Molecular function DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
Subterm of
GO:0006351
Biological process Transcription, DNA-templated The cellular synthesis of RNA on a template of DNA.
Subterm of
Part of
GO:0008270
Molecular function Zinc ion binding Interacting selectively and non-covalently with zinc (Zn) ions.
Subterm of
GO:0042025
Cellular component Host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi5g1v0147900.1
– DNA-directed RNA polymerase subunit; TAIR: AT3G57660.1 nuclear RNA polymerase A1; Swiss-Prot: sp|Q9SVY0|NRPA1_ARATH DNA-directed RNA polymerase I subunit 1; TrEMBL-Plants: tr|A0A151QTE2|A0A151QTE2_CAJCA DNA-directed RNA polymerase subunit; Found in the gene: LotjaGi5g1v0147900
Domains
28

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 100.00