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IPR015815 is a 3-hydroxyisobutyrate dehydrogenase-related.
<p>This entry contains related reductases/dehydrogenases:</p> <p> <ul> <li>3-hydroxyisobutyrate dehydrogenase (HIBADH) ([ec:1.1.1.31]) catalyzes the NAD-dependent, reversible oxidation of 3-hydroxbutyrate to methylmalonate [[cite:PUB00002541]]. In eukaryotes, it is a homodimeric mitochondrial protein involved in valine catabolism. In Pseudomonas aeruginosa [[cite:PUB00002721]] (gene mmsB), it is involved in the distal valine metabolic pathway.</li> <li>2-hydroxy-3-oxopropionate reductase ([ec:1.1.1.60]) catalyses the NAP(P)H dependent reduction of 2-hydroxy-3-oxopropionate (tartronate semialdehyde) to D-glycerate.</li> <li>2-(hydroxymethyl)glutarate dehydrogenase ([ec:1.1.1.291]) catalyses the conversion of 2-formylglutarate to (S)-2-hydroxymethylglutarate [[cite:PUB00051037]].</li> <li>L-threonate dehydrogenase catalyses oxidation of L-threonate to 2-oxo-tetronate [[cite:PUB00085179]].</li> <li>Putative oxidoreductase GLYR1, also known as 3-hydroxyisobutyrate dehydrogenase-like protein or nuclear protein NP60, which regulates p38 MAP kinase activity [[cite:PUB00057919]].</li> </ul> </p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable 3-hydroxyisobutyrate dehydrogenase-like 3, mitochondrial-like [Fragaria vesca subsp]. vesca] gi|470127985|ref|XP_004299936.1| | 15 | ||
| – | Hydroxyacid dehydrogenase/reductase; 6-phosphogluconate dehydrogenase, C-terminal-like [Medicago truncatula] gi|124359345|gb|ABD28508.2| | 15 | ||
| – | PREDICTED: probable 3-hydroxyisobutyrate dehydrogenase-like 1, mitochondrial-like [Cicer arietinum] gi|502138668|ref|XP_004503489.1| | 15 | ||
| – | PREDICTED: probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial-like isoform X1 [Cicer arietinum] gi|502080130|ref|XP_004486468.1| | 19 | ||
| – | 3-hydroxyisobutyrate dehydrogenase, putative; TAIR: AT1G17650.1 glyoxylate reductase 2; Swiss-Prot: sp|F4I907|GLYR2_ARATH Glyoxylate/succinic semialdehyde reductase 2, chloroplastic; TrEMBL-Plants: tr|G7IUG9|G7IUG9_MEDTR Glyoxylate/succinic semialdehyde reductase; Found in the gene: LotjaGi3g1v0026900 | 15 | ||
| – | 3-hydroxyisobutyrate dehydrogenase, putative; TAIR: AT1G17650.1 glyoxylate reductase 2; Swiss-Prot: sp|F4I907|GLYR2_ARATH Glyoxylate/succinic semialdehyde reductase 2, chloroplastic; TrEMBL-Plants: tr|G7IUG9|G7IUG9_MEDTR Glyoxylate/succinic semialdehyde reductase; Found in the gene: LotjaGi3g1v0026900 | 15 | ||
| – | 3-hydroxyisobutyrate dehydrogenase, putative; TAIR: AT3G25530.1 glyoxylate reductase 1; Swiss-Prot: sp|Q9LSV0|GLYR1_ARATH Glyoxylate/succinic semialdehyde reductase 1; TrEMBL-Plants: tr|A0A1J7GPF6|A0A1J7GPF6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0391100 | 17 | ||
| – | 6-phosphogluconate dehydrogenase family protein; TAIR: AT4G29120.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9SZE1|3HID1_ARATH Probable 3-hydroxyisobutyrate dehydrogenase-like 1, mitochondrial; TrEMBL-Plants: tr|I1K5Z3|I1K5Z3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0445200 | 15 | ||
| – | 3-hydroxyisobutyrate dehydrogenase; TAIR: AT4G20930.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9SUC0|3HIDH_ARATH Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A151T609|A0A151T609_CAJCA 3-hydroxyisobutyrate dehydrogenase; Found in the gene: LotjaGi6g1v0270100 | 17 | ||
| – | 3-hydroxyisobutyrate dehydrogenase; TAIR: AT4G20930.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9SUC0|3HIDH_ARATH Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A151T609|A0A151T609_CAJCA 3-hydroxyisobutyrate dehydrogenase; Found in the gene: LotjaGi6g1v0270100 | 17 | ||
| – | 6-phosphogluconate dehydrogenase-like protein; TAIR: AT1G71180.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q949M8|3HID3_ARATH Probable 3-hydroxyisobutyrate dehydrogenase-like 3, mitochondrial; TrEMBL-Plants: tr|W9QFQ0|W9QFQ0_9ROSA Putative oxidoreductase ykwC; Found in the gene: LotjaGi6g1v0360300 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF51735 | SUPERFAMILY | 1 | 9.09 |