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IPR015895

Source: InterPro

Description

IPR015895 is a Glutamyl-tRNA reductase, N-terminal.

<p>This entry represents the N-terminal domain of glutamyl-tRNA reductase ([ec:1.2.1.70]), which reduces glutamyl-tRNA to glutamate-1-semialdehyde during the first stage of tetrapyrrole biosynthesis by the C5 pathway [[cite:PUB00009744], [cite:PUB00005387]]. The enzyme requires NADPH as a cofactor. This N-terminal domain is the catalytic domain [[cite:PUB00075508]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0008883
Molecular function Glutamyl-tRNA reductase activity Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H(+) + NADPH.
Subterm of
GO:0033014
Biological process Tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
Subterm of
GO:0050661
Molecular function NADP binding Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
Subterm of
GO:0055114
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Subterm of

Associated Lotus transcripts 13

Transcript Name Description Predicted domains Domain count
Lj0g3v0090059.1
– Glutamyl-tRNA reductase [Medicago truncatula] gi|357466815|ref|XP_003603692.1|
Domains
21
Lj2g3v2161690.1
– PREDICTED: glutamyl-tRNA reductase 1, chloroplastic-like [Glycine max] gi|356552995|ref|XP_003544844.1|
Domains
21
Lj4g3v0409480.1
– PREDICTED: glutamyl-tRNA reductase 2, chloroplastic-like [Cicer arietinum] gi|502142275|ref|XP_004504877.1|
Domains
25
LotjaGi1g1v0132500.1
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A151U075|A0A151U075_CAJCA Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0132500
Domains
24
LotjaGi1g1v0132500.2
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A151U075|A0A151U075_CAJCA Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0132500
Domains
24
LotjaGi1g1v0132500.3
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A151U075|A0A151U075_CAJCA Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0132500
Domains
24
LotjaGi1g1v0132500.4
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A151U075|A0A151U075_CAJCA Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0132500
Domains
24
LotjaGi1g1v0132500.5
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A151U075|A0A151U075_CAJCA Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0132500
Domains
24
LotjaGi1g1v0414000.1
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A1J7IEK7|A0A1J7IEK7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0414000
Domains
23
LotjaGi1g1v0414000.2
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|G7J442|G7J442_MEDTR Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0414000
Domains
24
LotjaGi1g1v0414000.3
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|G7J442|G7J442_MEDTR Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0414000
Domains
24
LotjaGi1g1v0414000.4
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|G7J442|G7J442_MEDTR Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0414000
Domains
24
LotjaGi4g1v0042400.1
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A0B2SN36|A0A0B2SN36_GLYSO Glutamyl-tRNA reductase; Found in the gene: LotjaGi4g1v0042400
Domains
28

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd05213 CDD 1 7.69