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IPR018214

Source: InterPro

Description

IPR018214 is a Glutamyl-tRNA reductase, conserved site.

<p>Delta-aminolevulinic acid (ALA) is the obligatory precursor for the synthesis of all tetrapyrroles including porphyrin derivatives such as chlorophyll and heme. ALA can be synthesized via two different pathways: the Shemin (or C4) pathway which involves the single step condensation of succinyl-CoA and glycine and which is catalyzed by ALA synthase and via the C5 pathway from the five-carbon skeleton of glutamate. The C5 pathway operates in the chloroplast of plants and algae, in cyanobacteria, in some eubacteria and in archaebacteria [[cite:PUB00005387]].</p> <p>The initial step in the C5 pathway is carried out by glutamyl-tRNA reductase (GluTR) which catalyzes the NADP-dependent conversion of glutamate- tRNA(Glu) to glutamate-1-semialdehyde (GSA) with the concomitant release of tRNA(Glu) which can then be recharged with glutamate by glutamyl-tRNA synthetase [[cite:PUB00005387]].</p> <p>This entry represents the conserved site of glutamyl-tRNA reductase. This region seems important for the activity of the enzyme.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0008883
Molecular function Glutamyl-tRNA reductase activity Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H(+) + NADPH.
Subterm of
GO:0055114
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Subterm of

Associated Lotus transcripts 13

Transcript Name Description Predicted domains Domain count
Lj0g3v0090059.1
– Glutamyl-tRNA reductase [Medicago truncatula] gi|357466815|ref|XP_003603692.1|
Domains
21
Lj2g3v2161690.1
– PREDICTED: glutamyl-tRNA reductase 1, chloroplastic-like [Glycine max] gi|356552995|ref|XP_003544844.1|
Domains
21
Lj4g3v0409480.1
– PREDICTED: glutamyl-tRNA reductase 2, chloroplastic-like [Cicer arietinum] gi|502142275|ref|XP_004504877.1|
Domains
25
LotjaGi1g1v0132500.1
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A151U075|A0A151U075_CAJCA Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0132500
Domains
24
LotjaGi1g1v0132500.2
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A151U075|A0A151U075_CAJCA Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0132500
Domains
24
LotjaGi1g1v0132500.3
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A151U075|A0A151U075_CAJCA Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0132500
Domains
24
LotjaGi1g1v0132500.4
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A151U075|A0A151U075_CAJCA Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0132500
Domains
24
LotjaGi1g1v0132500.5
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A151U075|A0A151U075_CAJCA Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0132500
Domains
24
LotjaGi1g1v0414000.1
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A1J7IEK7|A0A1J7IEK7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0414000
Domains
23
LotjaGi1g1v0414000.2
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|G7J442|G7J442_MEDTR Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0414000
Domains
24
LotjaGi1g1v0414000.3
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|G7J442|G7J442_MEDTR Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0414000
Domains
24
LotjaGi1g1v0414000.4
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|G7J442|G7J442_MEDTR Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0414000
Domains
24
LotjaGi4g1v0042400.1
– Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A0B2SN36|A0A0B2SN36_GLYSO Glutamyl-tRNA reductase; Found in the gene: LotjaGi4g1v0042400
Domains
28

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd05213 CDD 1 7.69