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IPR036343 is a Glutamyl-tRNA reductase, N-terminal domain superfamily.
<p>Delta-aminolevulinic acid (ALA) is the obligatory precursor for the synthesis of all tetrapyrroles including porphyrin derivatives such as chlorophyll and heme. ALA can be synthesized via two different pathways: the Shemin (or C4) pathway which involves the single step condensation of succinyl-CoA and glycine and which is catalyzed by ALA synthase and via the C5 pathway from the five-carbon skeleton of glutamate. The C5 pathway operates in the chloroplast of plants and algae, in cyanobacteria, in some eubacteria and in archaebacteria [[cite:PUB00005387]].</p> <p>The initial step in the C5 pathway is carried out by glutamyl-tRNA reductase (GluTR) which catalyzes the NADP-dependent conversion of glutamate- tRNA(Glu) to glutamate-1-semialdehyde (GSA) with the concomitant release of tRNA(Glu) which can then be recharged with glutamate by glutamyl-tRNA synthetase [[cite:PUB00005387]].</p> <p>This entry represents the N-terminal domain superfamily of glutamyl-tRNA reductase ([ec:1.2.1.70]) [[cite:PUB00009744], [cite:PUB00005387]]. The enzyme requires NADPH as a cofactor. This domain has a Ferredoxin-like fold, which consits of an α+β sandwich with antiparallel β-sheet. This N-terminal domain is the catalytic domain [[cite:PUB00075508]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Glutamyl-tRNA reductase activity | Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H(+) + NADPH. | ||
| Biological process | Tetrapyrrole biosynthetic process | The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. | ||
| Molecular function | NADP binding | Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A151U075|A0A151U075_CAJCA Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0132500 | 24 | ||
| – | Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A151U075|A0A151U075_CAJCA Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0132500 | 24 | ||
| – | Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A151U075|A0A151U075_CAJCA Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0132500 | 24 | ||
| – | Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A151U075|A0A151U075_CAJCA Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0132500 | 24 | ||
| – | Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A151U075|A0A151U075_CAJCA Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0132500 | 24 | ||
| – | Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A1J7IEK7|A0A1J7IEK7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0414000 | 23 | ||
| – | Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|G7J442|G7J442_MEDTR Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0414000 | 24 | ||
| – | Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|G7J442|G7J442_MEDTR Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0414000 | 24 | ||
| – | Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|G7J442|G7J442_MEDTR Glutamyl-tRNA reductase; Found in the gene: LotjaGi1g1v0414000 | 24 | ||
| – | Glutamyl-tRNA reductase; TAIR: AT1G58290.1 Glutamyl-tRNA reductase family protein; Swiss-Prot: sp|P93111|HEM11_CUCSA Glutamyl-tRNA reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A0B2SN36|A0A0B2SN36_GLYSO Glutamyl-tRNA reductase; Found in the gene: LotjaGi4g1v0042400 | 28 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd05213 | CDD | 1 | 10.00 |