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IPR015944 is a Glycine-tRNA ligase, beta subunit.
<p>This entry represents the beta subunit of glycine-tRNA ligase.</p> <p>The aminoacyl-tRNA synthetases ([ec:6.1.1]) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology [[cite:PUB00007191]]. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold and are mostly monomeric, while class II aminoacyl-tRNA synthetases share an anti-parallel β-sheet formation, flanked by α-helices [[cite:PUB00000386]], and are mostly dimeric or multimeric. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic aci, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases.</p> <p>The 10 class I synthetases are considered to have in common the catalytic domain structure based on the Rossmann fold, which is totally different from the class II catalytic domain structure. The class I synthetases are further divided into three subclasses, a, b and c, according to sequence homology. No conserved structural features for tRNA recognition by class I synthetases have been established.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Nucleotide binding | Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. | ||
| Molecular function | Glycine-tRNA ligase activity | Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Cellular component | Cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | ||
| Biological process | Glycyl-tRNA aminoacylation | The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: glycine--tRNA ligase 2, chloroplastic/mitochondrial-like isoform X2 [Cicer arietinum] gi|502173505|ref|XP_004515345.1| | 8 | ||
| – | PREDICTED: glycine--tRNA ligase 2, chloroplastic/mitochondrial-like isoform X2 [Cicer arietinum] gi|502173505|ref|XP_004515345.1| | 11 | ||
| – | PREDICTED: glycine--tRNA ligase 2, chloroplastic/mitochondrial-like isoform X2 [Cicer arietinum] gi|502173505|ref|XP_004515345.1| | 5 | ||
| – | Glycine-tRNA ligase, alpha subunit; TAIR: AT3G48110.1 glycine-tRNA ligase; Swiss-Prot: sp|Q8L785|SYGM2_ARATH Glycine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|K7KEC9|K7KEC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0067600 | 24 | ||
| – | Glycine-tRNA ligase; TAIR: AT3G48110.1 glycine-tRNA ligase; Swiss-Prot: sp|Q8L785|SYGM2_ARATH Glycine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|K7KEC9|K7KEC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0067600 | 15 | ||
| – | Glycine-tRNA ligase, beta subunit; TAIR: AT3G48110.1 glycine-tRNA ligase; Swiss-Prot: sp|Q8L785|SYGM2_ARATH Glycine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|K7KEC9|K7KEC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0067600 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00211 | TIGRFAM | 1 | 16.67 |