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IPR016266 is a DNA polymerase epsilon, subunit B.
<p>DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure [[cite:PUB00010584]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Molecular function | DNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. | ||
| Biological process | DNA-dependent DNA replication | A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. | ||
| Cellular component | Epsilon DNA polymerase complex | A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA polymerase epsilon subunit 2-like [Glycine max] gi|356560075|ref|XP_003548321.1| | 6 | ||
| – | DNA polymerase epsilon subunit; TAIR: AT5G22110.1 DNA polymerase epsilon subunit B2; Swiss-Prot: sp|Q500V9|DPB2_ARATH DNA polymerase epsilon subunit B; TrEMBL-Plants: tr|A0A0L9VHK9|A0A0L9VHK9_PHAAN DNA polymerase epsilon subunit; Found in the gene: LotjaGi2g1v0185400 | 5 | ||
| – | DNA polymerase epsilon subunit; TAIR: AT5G22110.1 DNA polymerase epsilon subunit B2; Swiss-Prot: sp|Q500V9|DPB2_ARATH DNA polymerase epsilon subunit B; TrEMBL-Plants: tr|A0A0L9VHK9|A0A0L9VHK9_PHAAN DNA polymerase epsilon subunit; Found in the gene: LotjaGi2g1v0185400 | 4 | ||
| – | DNA polymerase epsilon subunit; TAIR: AT5G22110.1 DNA polymerase epsilon subunit B2; Swiss-Prot: sp|Q500V9|DPB2_ARATH DNA polymerase epsilon subunit B; TrEMBL-Plants: tr|A0A0L9VHK9|A0A0L9VHK9_PHAAN DNA polymerase epsilon subunit; Found in the gene: LotjaGi2g1v0185400 | 5 | ||
| – | DNA polymerase epsilon subunit; TAIR: AT5G22110.1 DNA polymerase epsilon subunit B2; Swiss-Prot: sp|Q500V9|DPB2_ARATH DNA polymerase epsilon subunit B; TrEMBL-Plants: tr|A0A0L9VHK9|A0A0L9VHK9_PHAAN DNA polymerase epsilon subunit; Found in the gene: LotjaGi2g1v0185400 | 5 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR12708 | PANTHER | 1 | 20.00 |