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IPR016295 is a Proteasome subunit beta 4.
<p>This group represents the beta type-4 subunit (MEROPS identifier T01.987) from the proteasome endopeptidase complex, which is one of the non-peptidase subunits. This subunit is known as beta type-7 in fungi.</p> <p>The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of non-lysosomal protein degradation in both the cytosol and nucleus [[cite:PUB00080972]]. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming an elongated α-β-β-α cylinder with a central cavity [[cite:PUB00080967], [cite:PUB00080970]]. The proteasome alpha and beta subunits are members of the N-terminal nucleophile (Ntn)-hydrolase superfamily [[cite:PUB00080969]]. Three of the beta subunits (beta1, beta2 and beta5) have an N-terminal threonine residue exposed as a nucleophile in peptide bond hydrolysis [[cite:PUB00080968]]. Eukaryotes have 7 alpha and 7 beta proteasome subunits while archaea have one of each [[cite:PUB00080971]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Threonine-type endopeptidase activity | Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: proteasome subunit beta type-4-like [Cicer arietinum] gi|502113510|ref|XP_004494673.1| | 14 | ||
– | PREDICTED: proteasome subunit beta type-4-like [Cicer arietinum] gi|502113510|ref|XP_004494673.1| | 14 | ||
– | Proteasome subunit beta type; TAIR: AT1G56450.1 20S proteasome beta subunit G1; Swiss-Prot: sp|Q7DLR9|PSB4_ARATH Proteasome subunit beta type-4; TrEMBL-Plants: tr|A0A0S3S5A0|A0A0S3S5A0_PHAAN Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0778500 | 14 | ||
– | Proteasome subunit beta type; TAIR: AT1G56450.1 20S proteasome beta subunit G1; Swiss-Prot: sp|Q7DLR9|PSB4_ARATH Proteasome subunit beta type-4; TrEMBL-Plants: tr|I1NC65|I1NC65_SOYBN Proteasome subunit beta type; Found in the gene: LotjaGi2g1v0362800 | 14 | ||
– | Proteasome subunit beta type; TAIR: AT1G56450.1 20S proteasome beta subunit G1; Swiss-Prot: sp|Q7DLR9|PSB4_ARATH Proteasome subunit beta type-4; TrEMBL-Plants: tr|I1NC66|I1NC66_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0362800 | 11 | ||
– | Proteasome subunit beta type; TAIR: AT1G56450.1 20S proteasome beta subunit G1; Swiss-Prot: sp|Q7DLR9|PSB4_ARATH Proteasome subunit beta type-4; TrEMBL-Plants: tr|I1NC66|I1NC66_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0362800 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd03760 | CDD | 1 | 16.67 |