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IPR016295

Description

IPR016295 is a Proteasome subunit beta 4.

<p>This group represents the beta type-4 subunit (MEROPS identifier T01.987) from the proteasome endopeptidase complex, which is one of the non-peptidase subunits. This subunit is known as beta type-7 in fungi.</p> <p>The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of non-lysosomal protein degradation in both the cytosol and nucleus [[cite:PUB00080972]]. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming an elongated α-β-β-α cylinder with a central cavity [[cite:PUB00080967], [cite:PUB00080970]]. The proteasome alpha and beta subunits are members of the N-terminal nucleophile (Ntn)-hydrolase superfamily [[cite:PUB00080969]]. Three of the beta subunits (beta1, beta2 and beta5) have an N-terminal threonine residue exposed as a nucleophile in peptide bond hydrolysis [[cite:PUB00080968]]. Eukaryotes have 7 alpha and 7 beta proteasome subunits while archaea have one of each [[cite:PUB00080971]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Threonine-type endopeptidase activity Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
PREDICTED: proteasome subunit beta type-4-like [Cicer arietinum] gi|502113510|ref|XP_004494673.1| 14
PREDICTED: proteasome subunit beta type-4-like [Cicer arietinum] gi|502113510|ref|XP_004494673.1| 14
Proteasome subunit beta type; TAIR: AT1G56450.1 20S proteasome beta subunit G1; Swiss-Prot: sp|Q7DLR9|PSB4_ARATH Proteasome subunit beta type-4; TrEMBL-Plants: tr|A0A0S3S5A0|A0A0S3S5A0_PHAAN Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0778500 14
Proteasome subunit beta type; TAIR: AT1G56450.1 20S proteasome beta subunit G1; Swiss-Prot: sp|Q7DLR9|PSB4_ARATH Proteasome subunit beta type-4; TrEMBL-Plants: tr|I1NC65|I1NC65_SOYBN Proteasome subunit beta type; Found in the gene: LotjaGi2g1v0362800 14
Proteasome subunit beta type; TAIR: AT1G56450.1 20S proteasome beta subunit G1; Swiss-Prot: sp|Q7DLR9|PSB4_ARATH Proteasome subunit beta type-4; TrEMBL-Plants: tr|I1NC66|I1NC66_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0362800 11
Proteasome subunit beta type; TAIR: AT1G56450.1 20S proteasome beta subunit G1; Swiss-Prot: sp|Q7DLR9|PSB4_ARATH Proteasome subunit beta type-4; TrEMBL-Plants: tr|I1NC66|I1NC66_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0362800 11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd03760 CDD 1 16.67