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IPR016314 is a Cell division protein Cdc6/18.
<p>This group represents the cell division control protein Cdc6 and Cdc18, which are essential initiation factors for DNA replication [[cite:PUB00074529]].</p> <p>Cdc6 appears to have an important and perhaps unique dual role in S phase, it is first required for the initiation of DNA replication and then actively participates in the suppression of nuclear division. It interacts with the origin recognition complex (ORC). It targeted for degradation by the E3 ubiquitin ligase complex SCF (Cdc4) [[cite:PUB00062022], [cite:PUB00062023]].</p> <p>Cdc18 is part of the checkpoint control that prevents mitosis from occurring until S phase is completed. It plays a key role in coupling S phase to start and mitosis. It acts at the initiation of DNA replication and plays a major role in controlling the onset of S-phase. Together with orp1, it is involved in the maintenance of replication forks and activation of cds1-dependent S-phase checkpoint [[cite:PUB00062024], [cite:PUB00062025], [cite:PUB00062026], [cite:PUB00062027], [cite:PUB00062028]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | DNA replication initiation | The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate. | ||
| Biological process | Cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: cell division control protein 6 homolog [Cicer arietinum] gi|502129264|ref|XP_004500243.1| | 19 | ||
| – | Cell division control 6; TAIR: AT1G07270.1 Cell division control, Cdc6; Swiss-Prot: sp|Q8W032|CDC6B_ARATH Cell division control protein 6 homolog B; TrEMBL-Plants: tr|I1KYU8|I1KYU8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0112500 | 22 | ||
| – | Cell division control 6; TAIR: AT1G07270.1 Cell division control, Cdc6; Swiss-Prot: sp|Q8W032|CDC6B_ARATH Cell division control protein 6 homolog B; TrEMBL-Plants: tr|I1KYU8|I1KYU8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0112500 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |