Description

IPR017000 is a Membrane-anchored ubiquitin-fold protein.

<p>Ubiquitin-fold proteins are an important class of eukaryotic post-translational modifiers [[cite:PUB00043569], [cite:PUB00043568]]. They are generally short proteins (less than 200 amino acids) which contain the core β-grasp fold (also known as the ubiquitin fold) and a C-terminal extension which enables their attachment to other proteins through the terminal carboxyl group. Protein-conjugated ubiquitins have been implicated an a wide variety of cellular process including proteolysis, DNA repair, transcription and autophagy Some ubiquitin-like proteins are not conjugated to proteins, but are instead anchored to the cell membrane by attachment to phospholipids or isoprenes. The functions of these membrane-associated proteins are not generally well understood. In the case of isoprene attachemnet, the prenyl group may also play a role in enhancing protein-protein interactions.</p> <p>This entry represents a group of membrane-associated ubiquitin-fold proteins found in plants and animals [[cite:PUB00043568]]. In Arabidopsis, membrane-anchored ubiquitin-fold (MUB) proteins recruit and dock specific E2s to the plasma membrane. They appear to interact noncovalently with an E2 surface opposite the active site that forms a covalent linkage with Ub [[cite:PUB00076959]]. The animal homologues of MUBs, also known as UBL3, have also been identified as ubiquitin-like proteins [[cite:PUB00076960]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: