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IPR017334 is a Eukaryotic translation initiation factor 3 subunit G.
<p>At least eleven different protein factors are involved in initiation of protein synthesis in eukaryotes. Binding of initiator tRNA and mRNA to the 40S subunit requires the presence of the translation initiation factors eIF-2 and eIF-3, with eIF-3 being particularly important for 80S ribosome dissociation and mRNA binding [[cite:PUB00054024]]. eIF-3 is the most complex translation inititation factor, consisting of about 13 putative subunits and having a molecular weight of between 550 - 700kDa in mammalian cells. Subunits are designated eIF-3a - eIF-3m; the large number of subunits means that the interactions between the individual subunits that make up the eIF-3 complex are complex and varied [[cite:PUB00005773]]. Subunit G is required for eIF3 integrity.</p> <p>Eukaryotic translation initiation factor 3 subunit G (eIF3g) is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome [[cite:PUB00005773], [cite:PUB00064801]]. eIF3g can bind 18S rRNA [[cite:PUB00056123]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. | ||
| Cellular component | Cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | ||
| Cellular component | Eukaryotic translation initiation factor 3 complex | A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: eukaryotic translation initiation factor 3 subunit G-like [Glycine max] gi|356567603|ref|XP_003552007.1| | 16 | ||
| – | Eukaryotic translation initiation factor 3 subunit G; TAIR: AT3G11400.1 eukaryotic translation initiation factor 3G1; Swiss-Prot: sp|Q6DRC4|EIF3G_DANRE Eukaryotic translation initiation factor 3 subunit G; TrEMBL-Plants: tr|A0A1J7G0E8|A0A1J7G0E8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0137500 | 19 | ||
| – | Eukaryotic translation initiation factor 3 subunit G; TAIR: AT3G11400.1 eukaryotic translation initiation factor 3G1; Swiss-Prot: sp|A7SKE9|EIF3G_NEMVE Eukaryotic translation initiation factor 3 subunit G; TrEMBL-Plants: tr|A0A1J7G0E8|A0A1J7G0E8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0336600 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |