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IPR017439 is a Amidohydrolase.
<p>This entry represents a clade of the amidohydrolases. They classified as metallopeptidases belonging to MEROPS peptidase family M20 (clan MH), subfamily M20D. Included within this group are hydrolases of hippurate (N-benzylglycine), indoleacetic acid (IAA) N-conjugates of amino acids, N-acetyl-L-amino acids and aminobenzoylglutamate. These hydrolases are of the carboxypeptidase-type, most likely utilizing a zinc ion in the active site.</p> <p>In higher plants, the growth hormone indole-3-acetic acid (IAA or auxin) is stored conjugated to sugar moieties via an ester linkage or to amino acids or peptides via an amide. More than 95% of the hormone in a plant can be found in the conjugated form, leaving only a small amount of free hormone available to stimulate and control cellular growth. The overall levels of active IAA in a plant can be controlled not only by the amount of IAA synthesized, but also by the quantity of IAA that is released from the conjugated state into the free state. Amidohydrolases cleave the amide bond between the auxin and the conjugated amino acid. Several IAA amidohydrolases have been isolated from Arabidopsis thaliana (Mouse-ear cress), each of these enzymes has different substrate specificities. The A. thaliana IAA amidohydrolase, IAR3, is able to cleave IAA-Alanine, while products of the other amidohydrolase genes, known as the ILR1-like family of hydrolases (ILR1, ILL1, ILL2, ILL3, and ILL5), cleave primarily IAA-Phenylalanine and IAA-Leucine [[cite:PUB00014785]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: IAA-amino acid hydrolase ILR1-like 6-like [Glycine max] gi|356515913|ref|XP_003526641.1| | 22 | ||
| – | PREDICTED: IAA-amino acid hydrolase ILR1-like 5-like [Glycine max] gi|356509130|ref|XP_003523305.1| | 12 | ||
| – | PREDICTED: IAA-amino acid hydrolase ILR1-like 4-like [Glycine max] gi|356550474|ref|XP_003543612.1| | 12 | ||
| – | PREDICTED: IAA-amino acid hydrolase ILR1-like 4-like [Glycine max] gi|356550474|ref|XP_003543612.1| | 21 | ||
| – | PREDICTED: IAA-amino acid hydrolase ILR1-like 4-like [Glycine max] gi|356522765|ref|XP_003530016.1| | 21 | ||
| – | PREDICTED: IAA-amino acid hydrolase ILR1-like 4-like [Glycine max] gi|356522765|ref|XP_003530016.1| | 18 | ||
| – | PREDICTED: IAA-amino acid hydrolase ILR1-like 4-like [Glycine max] gi|356522765|ref|XP_003530016.1| | 19 | ||
| – | PREDICTED: IAA-amino acid hydrolase ILR1-like 4-like [Glycine max] gi|356522765|ref|XP_003530016.1| | 18 | ||
| – | IAA-amino acid hydrolase ILR1, putative; TAIR: AT1G44350.1 IAA-amino acid hydrolase ILR1-like 6; Swiss-Prot: sp|Q8VYX0|ILL6_ARATH IAA-amino acid hydrolase ILR1-like 6; TrEMBL-Plants: tr|I1KAC2|I1KAC2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0262400 | 22 | ||
| – | IAA-amino acid hydrolase ILR1, putative; TAIR: AT5G54140.1 IAA-leucine-resistant (ILR1)-like 3; Swiss-Prot: sp|Q7XUA8|ILL5_ORYSJ IAA-amino acid hydrolase ILR1-like 5; TrEMBL-Plants: tr|I3STS5|I3STS5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0300800 | 22 | ||
| – | IAA-amino acid hydrolase ILR1-like protein; TAIR: AT1G51760.1 peptidase M20/M25/M40 family protein; Swiss-Prot: sp|O04373|ILL4_ARATH IAA-amino acid hydrolase ILR1-like 4; TrEMBL-Plants: tr|I1M5E5|I1M5E5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0022900 | 21 | ||
| – | IAA-amino acid hydrolase ILR1-like protein; TAIR: AT1G51760.1 peptidase M20/M25/M40 family protein; Swiss-Prot: sp|O04373|ILL4_ARATH IAA-amino acid hydrolase ILR1-like 4; TrEMBL-Plants: tr|I3T1Y7|I3T1Y7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0428600 | 22 | ||
| – | IAA-amino acid hydrolase ILR1-like protein; TAIR: AT1G51760.1 peptidase M20/M25/M40 family protein; Swiss-Prot: sp|O04373|ILL4_ARATH IAA-amino acid hydrolase ILR1-like 4; TrEMBL-Plants: tr|I3T1Y7|I3T1Y7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0428600 | 22 | ||
| – | IAA-amino acid hydrolase ILR1-like protein; TAIR: AT1G51760.1 peptidase M20/M25/M40 family protein; Swiss-Prot: sp|O04373|ILL4_ARATH IAA-amino acid hydrolase ILR1-like 4; TrEMBL-Plants: tr|I3T1Y7|I3T1Y7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0428600 | 17 | ||
| – | IAA-amino acid hydrolase ILR1-like protein; TAIR: AT1G51760.1 peptidase M20/M25/M40 family protein; Swiss-Prot: sp|O04373|ILL4_ARATH IAA-amino acid hydrolase ILR1-like 4; TrEMBL-Plants: tr|I3T1Y7|I3T1Y7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0428700 | 19 | ||
| – | IAA-amino acid hydrolase ILR1-like protein; TAIR: AT1G51760.1 peptidase M20/M25/M40 family protein; Swiss-Prot: sp|O04373|ILL4_ARATH IAA-amino acid hydrolase ILR1-like 4; TrEMBL-Plants: tr|I3T1Y7|I3T1Y7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0428800 | 22 | ||
| – | IAA-amino acid hydrolase ILR1-like protein; TAIR: AT1G51760.1 peptidase M20/M25/M40 family protein; Swiss-Prot: sp|O04373|ILL4_ARATH IAA-amino acid hydrolase ILR1-like 4; TrEMBL-Plants: tr|I3T1Y7|I3T1Y7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0429000 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd08017 | CDD | 1 | 5.88 |