Description

IPR002933 is a Peptidase M20.

<p>This group of proteins contains the metallopeptidases and non-peptidase homologues (amidohydrolases) that belong to the MEROPS peptidase family M20 (clan MH) [[cite:PUB00003579]]. The peptidases of this clan have two catalytic zinc ions at the active site, bound by His/Asp, Asp, Glu, Asp/Glu and His. The catalysed reaction involves the release of an N-terminal amino acid, usually neutral or hydrophobic, from a polypeptide [[cite:PUB00003579]]. The peptidase M20 family has four subfamilies:</p> <ul><li>M20A -type example, glutamate carboxypeptidase from Pseudomonas sp. RS16 ([swissprot:P06621])</li> <li>M20B -type example, peptidase T from Escherichia coli ([swissprot:P29745])</li> <li>M20C -type example, X-His dipeptidase from E. coli ([swissprot:P15288])</li> <li>M20D -type example, carboxypeptidase Ss1 from Sulfolobus solfataricus ([swissprot:P80092])</li> </ul> <p>Homologues from the family that are not peptidases include:</p> <ul> <li>Acetylornithine deacetylase, which releases an acetyl group and L-ornithine from N(2)-acetyl-L-ornithine [[cite:PUB00014890]]</li> <li>N-acetyldiaminopimelate deacetylase, which catalyses the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate [[cite:PUB00085192]]</li> <li>N-carbamoyl-L-amino-acid hydrolase, which converts D,L-5-monosubstituted hydantoins into D-or L-amino acids [[cite:PUB00019732]]</li> <li>Aminoacylase-1, which hydrolyses N-acylated or N-acetylated amino acids [[cite:PUB00030157]]</li> <li>Succinyl-diaminopimelate desuccinylase ([ec:3.5.1.18]), which catalyses the hydrolysis of N-succinyl-L,L-diaminopimelic acid, forming succinate and LL-2,6-diaminoheptanedioate (DAP, a component of bacterial cell walls) [[cite:PUB00079915]]</li> </ul>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 39

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: