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IPR017597 is a Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y.
<p>Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH) [[cite:PUB00044722]]. This entry represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. The pyruvate dehydrogenase complex catalyses the overall conversion of pyruvate to acetyl-CoA and carbon dioxide. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Pyruvate dehydrogenase (acetyl-transferring) activity | Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. | ||
| Biological process | Acetyl-CoA biosynthetic process from pyruvate | The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. | ||
| Cellular component | Intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Pyruvate dehydrogenase, partial [Citrus x paradisi] gi|68138987|gb|AAY86036.1| | 13 | ||
| – | PREDICTED: pyruvate dehydrogenase E1 component subunit alpha-like [Glycine max] gi|356559679|ref|XP_003548126.1| | 11 | ||
| – | Pyruvate dehydrogenase E1 component subunit alpha; TAIR: AT1G59900.1 pyruvate dehydrogenase complex E1 alpha subunit; Swiss-Prot: sp|P52902|ODPA_PEA Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; TrEMBL-Plants: tr|V7CHA1|V7CHA1_PHAVU Pyruvate dehydrogenase E1 component subunit alpha; Found in the gene: LotjaGi2g1v0312700 | 13 | ||
| – | Pyruvate dehydrogenase E1 component subunit alpha; TAIR: AT1G01090.1 pyruvate dehydrogenase E1 alpha; Swiss-Prot: sp|O24457|ODPA3_ARATH Pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic; TrEMBL-Plants: tr|A0A0B2Q7E3|A0A0B2Q7E3_GLYSO Pyruvate dehydrogenase E1 component subunit alpha; Found in the gene: LotjaGi3g1v0403700 | 11 | ||
| – | Pyruvate dehydrogenase E1 component subunit alpha; TAIR: AT1G01090.1 pyruvate dehydrogenase E1 alpha; Swiss-Prot: sp|O24457|ODPA3_ARATH Pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic; TrEMBL-Plants: tr|A0A0B2Q7E3|A0A0B2Q7E3_GLYSO Pyruvate dehydrogenase E1 component subunit alpha; Found in the gene: LotjaGi3g1v0403700 | 11 | ||
| – | Pyruvate dehydrogenase E1 component subunit alpha; TAIR: AT1G01090.1 pyruvate dehydrogenase E1 alpha; Swiss-Prot: sp|O24457|ODPA3_ARATH Pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic; TrEMBL-Plants: tr|A0A0B2Q7E3|A0A0B2Q7E3_GLYSO Pyruvate dehydrogenase E1 component subunit alpha; Found in the gene: LotjaGi3g1v0403700 | 11 | ||
| – | Pyruvate dehydrogenase E1 component subunit alpha; TAIR: AT1G01090.1 pyruvate dehydrogenase E1 alpha; Swiss-Prot: sp|O24457|ODPA3_ARATH Pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic; TrEMBL-Plants: tr|A0A0B2Q7E3|A0A0B2Q7E3_GLYSO Pyruvate dehydrogenase E1 component subunit alpha; Found in the gene: LotjaGi3g1v0403700 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02000 | CDD | 1 | 14.29 |