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IPR017942 is a Lipid-binding serum glycoprotein, N-terminal.
<p>This entry represents the N-terminal domain found in several lipid-binding serum glycoproteins. The N- and C-terminal domains share a similar two-layer α/β structure, but they show little sequence identity. Proteins containing this N-terminal domain include:</p> <ul><li>Bactericidal permeability-increasing protein (BPI)</li> <li>Lipopolysaccharide-binding protein (LBP)</li> <li>Cholesteryl ester transfer protein (CETP)</li> <li>Phospholipid transfer protein (PLTP)</li> <li>Palate, lung and nasal epithelium carcinoma-associated protein (PLUNC)</li></ul> <p>Bactericidal permeability-increasing protein (BPI) is a potent antimicrobial protein of 456 residues that binds to and neutralises lipopolysaccharides from the outer membrane of Gram-negative bacteria [[cite:PUB00005225]]. BPI contains two domains that adopt the same structural fold, even though they have little sequence similarity [[cite:PUB00021529]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Lipid binding | Interacting selectively and non-covalently with a lipid. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Lipid-binding serum glycoprotein family protein isoform 2 [Theobroma cacao] gi|508701509|gb|EOX93405.1| | 13 | ||
| – | Lipid-binding serum glycoprotein family protein isoform 1 [Theobroma cacao] gi|508701508|gb|EOX93404.1| | 25 | ||
| – | Bactericidal permeability-increasing protein [Medicago truncatula] gi|357494733|ref|XP_003617655.1| | 21 | ||
| – | Bactericidal permeability-increasing protein [Medicago truncatula] gi|357494733|ref|XP_003617655.1| | 21 | ||
| – | Lipid-binding serum glycoprotein family protein, putative; TAIR: AT1G04970.1 lipid-binding serum glycoprotein family protein; Swiss-Prot: sp|Q9MAU5|Y1049_ARATH Putative BPI/LBP family protein At1g04970; TrEMBL-Plants: tr|I1M6L4|I1M6L4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0023000 | 18 | ||
| – | Lipid-binding serum glycoprotein; TAIR: AT1G04970.2 lipid-binding serum glycoprotein family protein; Swiss-Prot: sp|Q9MAU5|Y1049_ARATH Putative BPI/LBP family protein At1g04970; TrEMBL-Plants: tr|A0A0B2SIV3|A0A0B2SIV3_GLYSO Putative BPI/LBP family protein; Found in the gene: LotjaGi1g1v0069000 | 16 | ||
| – | Lipid-binding serum glycoprotein; TAIR: AT1G04970.1 lipid-binding serum glycoprotein family protein; Swiss-Prot: sp|Q9MAU5|Y1049_ARATH Putative BPI/LBP family protein At1g04970; TrEMBL-Plants: tr|A0A0B2SIV3|A0A0B2SIV3_GLYSO Putative BPI/LBP family protein; Found in the gene: LotjaGi1g1v0069000 | 23 | ||
| – | Lipid-binding serum glycoprotein; TAIR: AT1G04970.1 lipid-binding serum glycoprotein family protein; Swiss-Prot: sp|Q9MAU5|Y1049_ARATH Putative BPI/LBP family protein At1g04970; TrEMBL-Plants: tr|A0A0B2SIV3|A0A0B2SIV3_GLYSO Putative BPI/LBP family protein; Found in the gene: LotjaGi1g1v0069000 | 12 | ||
| – | Lipid-binding serum glycoprotein family protein, putative; TAIR: AT1G04970.1 lipid-binding serum glycoprotein family protein; Swiss-Prot: sp|Q9MAU5|Y1049_ARATH Putative BPI/LBP family protein At1g04970; TrEMBL-Plants: tr|V7BPL8|V7BPL8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0153400 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00025 | CDD | 1 | 11.11 |