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IPR018171

Source: InterPro

Description

IPR018171 is a Peptidyl-tRNA hydrolase, conserved site.

<p>This entry represents two conserved regions that each contain an histidine. The first of these regions is located in the N-terminal part of the protein, the other in the central part.</p> <p>Peptidyl-tRNA hydrolase ([ec:3.1.1.29]) (PTH) is a bacterial enzyme that cleaves peptidyl-tRNA or N-acyl-aminoacyl-tRNA to yield free peptides or N-acyl-amino acids and tRNA. The natural substrate for this enzyme may be peptidyl-tRNA which drop off the ribosome during protein synthesis [[cite:PUB00001213], [cite:PUB00001861]]. Bacterial PTH has been found to be evolutionary related to a yeast protein [[cite:PUB00005030]]. This enzyme is interesting as a potential target for the discovery of new antimicrobial agents as it is critical for the viability of bacteria [[cite:PUB00106491]}. It folds into a single α/β globular domain with seven β-strands forming a twisted mixed central β-sheet, surrounded by a total of six helices [[cite:PUB00062567]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004045
Molecular function Aminoacyl-tRNA hydrolase activity Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.
Subterm of

Associated Lotus transcripts 8

Transcript Name Description Predicted domains Domain count
Lj0g3v0191739.1
– PREDICTED: peptidyl-tRNA hydrolase, chloroplastic-like [Cicer arietinum] gi|502138474|ref|XP_004503420.1|
Domains
16
Lj4g3v2604250.1
– PREDICTED: peptidyl-tRNA hydrolase, mitochondrial-like [Cicer arietinum] gi|502140733|ref|XP_004504315.1|
Domains
11
Lj4g3v3098140.1
– PREDICTED: peptidyl-tRNA hydrolase, chloroplastic-like [Cicer arietinum] gi|502138474|ref|XP_004503420.1|
Domains
17
LotjaGi1g1v0548200.1
– Peptidyl-tRNA hydrolase family protein; TAIR: AT5G16140.1 Peptidyl-tRNA hydrolase family protein; Swiss-Prot: sp|Q9LF14|CRS2B_ARATH Chloroplastic group IIB intron splicing facilitator CRS2-B, chloroplastic; TrEMBL-Plants: tr|I3SEB0|I3SEB0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0548200
Domains
12
LotjaGi1g1v0548200.2
– Peptidyl-tRNA hydrolase family protein; TAIR: AT5G16140.1 Peptidyl-tRNA hydrolase family protein; Swiss-Prot: sp|Q9LF14|CRS2B_ARATH Chloroplastic group IIB intron splicing facilitator CRS2-B, chloroplastic; TrEMBL-Plants: tr|I3SEB0|I3SEB0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0548200
Domains
12
LotjaGi4g1v0350500.1
– Peptidyl-tRNA hydrolase family protein; TAIR: AT1G18440.1 Peptidyl-tRNA hydrolase family protein; Swiss-Prot: sp|Q8GW64|PTHC_ARATH Peptidyl-tRNA hydrolase, chloroplastic; TrEMBL-Plants: tr|G7L906|G7L906_MEDTR Peptidyl-tRNA hydrolase family protein; Found in the gene: LotjaGi4g1v0350500
Domains
13
LotjaGi4g1v0376500.1
– Peptidyl-tRNA hydrolase family protein; TAIR: AT5G19830.1 Peptidyl-tRNA hydrolase family protein; Swiss-Prot: sp|Q6NLS8|PTHM_ARATH Peptidyl-tRNA hydrolase, mitochondrial; TrEMBL-Plants: tr|V7CMJ9|V7CMJ9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0376500
Domains
12
LotjaGi4g1v0451600.1
– Peptidyl-tRNA hydrolase family protein; TAIR: AT1G18440.1 Peptidyl-tRNA hydrolase family protein; Swiss-Prot: sp|Q8GW64|PTHC_ARATH Peptidyl-tRNA hydrolase, chloroplastic; TrEMBL-Plants: tr|G7L906|G7L906_MEDTR Peptidyl-tRNA hydrolase family protein; Found in the gene: LotjaGi4g1v0451600
Domains
18

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR00447 TIGRFAM 1 12.50