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IPR018252 is a Annexin repeat, conserved site.
<p>Annexins [[cite:PUB00000662], [cite:PUB00001395], [cite:PUB00000969], [cite:PUB00005347], [cite:PUB00000296], [cite:PUB00005527], [cite:PUB00093767], [cite:PUB00093770]] are a group of calcium-binding proteins that associate reversibly with membranes. They bind to phospholipid bilayers in the presence of micromolar free calcium concentration. The binding is specific for calcium and for acidic phospholipids. Annexins have been claimed to be involved in cytoskeletal interactions, phospholipase inhibition, intracellular signaling, anticoagulation, and membrane fusion. Annexins are widely distributed among eukaryotes but largely absent in prokaryotes and yeast. They are classified according to the evolutionary divisions of the eukaryotes into five families: A (ANXA, vertebrates, including humans), B (ANXB, invertebrates), C (ANXC, fungi), D (ANXD, true plants), E (ANXE, protists).</p> <p>Each of these proteins consist of a unique N-terminal domain followed by four or eight copies (in annexin A6) of a conserved segment of approximately 70 residues. The tertiary structure of annexins is evolutionary conserved; a single molecule resembles a slightly curved disk with the calcium and phospholipid-binding sites located on the more convex surface and the more concave surface facing the cytoplasm. Each single annexin repeat (sometimes known as an 'endonexin fold') is comprised of five α-helices(A-E). Four of them (A, B, D and E) are arranged parallel and form a tightly packed helix-loop-helix bundle. In contrast, helix C is almost perpendicular and covers the remaining four on the surface. Each of the repeats has the potential to have a type II Ca(2)-binding bipartite motif, located on two different α-helices (GxGT-(38-40 residues)-D/E), but typically some of them are non-functional. The core of the helix bundle is composed largely of hydrophobic residues, while hydrophilic residues are exposed on the surface of the protein and between the repeats. The N-terminal domain of variable length, amino acid composition, and determinants of hydrophobicity plays an important role in mediating the interaction of annexins with other intracellular protein partners, such as those of the S100 family cytoplasmic proteins [[cite:PUB00093767], [cite:PUB00093770], [cite:PUB00001198]].</p> <p>This region spans positions 9 to 61 of the repeat and includes the only perfectly conserved residue (an arginine in position 22).</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Calcium ion binding | Interacting selectively and non-covalently with calcium ions (Ca2+). | ||
Molecular function | Calcium-dependent phospholipid binding | Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: annexin D3-like [Glycine max] gi|356556843|ref|XP_003546730.1| | 12 | ||
– | PREDICTED: annexin-like protein RJ4-like [Glycine max] gi|356508416|ref|XP_003522953.1| | 13 | ||
– | Annexin-like protein RJ4 [Medicago truncatula] gi|357456735|ref|XP_003598648.1| | 13 | ||
– | Annexin-like protein RJ4 [Medicago truncatula] gi|357456735|ref|XP_003598648.1| | 13 | ||
– | PREDICTED: annexin-like protein RJ4-like isoform X3 [Cicer arietinum] gi|502158052|ref|XP_004511012.1| | 13 | ||
– | PREDICTED: annexin D5-like [Cicer arietinum] gi|502164946|ref|XP_004513341.1| | 11 | ||
– | PREDICTED: annexin D5-like [Cicer arietinum] gi|502164946|ref|XP_004513341.1| | 11 | ||
– | PREDICTED: annexin D2-like [Cicer arietinum] gi|502140127|ref|XP_004504069.1| | 13 | ||
– | PREDICTED: LOW QUALITY PROTEIN: annexin D5-like [Glycine max] gi|356531118|ref|XP_003534125.1| | 11 | ||
– | PREDICTED: annexin D5-like [Cicer arietinum] gi|502164946|ref|XP_004513341.1| | 10 | ||
– | PREDICTED: annexin D5-like [Glycine max] gi|356524724|ref|XP_003530978.1| | 10 | ||
– | PREDICTED: annexin D5-like [Cicer arietinum] gi|502164756|ref|XP_004513248.1| | 10 | ||
– | Annexin; TAIR: AT1G35720.1 annexin 1; Swiss-Prot: sp|Q9SYT0|ANXD1_ARATH Annexin D1; TrEMBL-Plants: tr|I3SZS2|I3SZS2_LOTJA Annexin; Found in the gene: LotjaGi1g1v0146400 | 15 | ||
– | Annexin; TAIR: AT1G35720.1 annexin 1; Swiss-Prot: sp|Q9SYT0|ANXD1_ARATH Annexin D1; TrEMBL-Plants: tr|I3SZS2|I3SZS2_LOTJA Annexin; Found in the gene: LotjaGi1g1v0146400 | 15 | ||
– | Annexin; TAIR: AT1G68090.1 annexin 5; Swiss-Prot: sp|Q9C9X3|ANXD5_ARATH Annexin D5; TrEMBL-Plants: tr|I1ND51|I1ND51_SOYBN Annexin; Found in the gene: LotjaGi2g1v0006300 | 13 | ||
– | Annexin; TAIR: AT1G68090.1 annexin 5; Swiss-Prot: sp|Q9C9X3|ANXD5_ARATH Annexin D5; TrEMBL-Plants: tr|I1ND51|I1ND51_SOYBN Annexin; Found in the gene: LotjaGi2g1v0006300 | 13 | ||
– | Annexin; TAIR: AT1G68090.1 annexin 5; Swiss-Prot: sp|Q9C9X3|ANXD5_ARATH Annexin D5; TrEMBL-Plants: tr|A0A151QYP8|A0A151QYP8_CAJCA Annexin; Found in the gene: LotjaGi2g1v0006300 | 13 | ||
– | Annexin; TAIR: AT1G68090.1 annexin 5; Swiss-Prot: sp|Q9C9X3|ANXD5_ARATH Annexin D5; TrEMBL-Plants: tr|A0A0R0E5G1|A0A0R0E5G1_SOYBN Annexin; Found in the gene: LotjaGi2g1v0006300 | 13 | ||
– | Annexin; TAIR: AT1G68090.1 annexin 5; Swiss-Prot: sp|Q9C9X3|ANXD5_ARATH Annexin D5; TrEMBL-Plants: tr|I3SXY1|I3SXY1_LOTJA Annexin; Found in the gene: LotjaGi2g1v0190700 | 13 | ||
– | Annexin; TAIR: AT1G68090.2 annexin 5; Swiss-Prot: sp|Q9C9X3|ANXD5_ARATH Annexin D5; TrEMBL-Plants: tr|C6T8A9|C6T8A9_SOYBN Annexin; Found in the gene: LotjaGi2g1v0190700 | 13 | ||
– | Annexin; TAIR: AT1G68090.1 annexin 5; Swiss-Prot: sp|Q9C9X3|ANXD5_ARATH Annexin D5; TrEMBL-Plants: tr|I3SXY1|I3SXY1_LOTJA Annexin; Found in the gene: LotjaGi2g1v0190800 | 13 | ||
– | Annexin; TAIR: AT1G68090.1 annexin 5; Swiss-Prot: sp|Q9C9X3|ANXD5_ARATH Annexin D5; TrEMBL-Plants: tr|I3SXY1|I3SXY1_LOTJA Annexin; Found in the gene: LotjaGi2g1v0190800 | 13 | ||
– | Annexin; TAIR: AT2G38760.1 annexin 3; Swiss-Prot: sp|Q9SE45|ANXD3_ARATH Annexin D3; TrEMBL-Plants: tr|A0A151TPW7|A0A151TPW7_CAJCA Annexin; Found in the gene: LotjaGi3g1v0062500 | 14 | ||
– | Annexin; TAIR: AT5G12380.1 annexin 8; Swiss-Prot: sp|P51074|ANX4_FRAAN Annexin-like protein RJ4; TrEMBL-Plants: tr|I3SNL5|I3SNL5_LOTJA Annexin; Found in the gene: LotjaGi3g1v0062800 | 15 | ||
– | Annexin; TAIR: AT5G12380.1 annexin 8; Swiss-Prot: sp|P51074|ANX4_FRAAN Annexin-like protein RJ4; TrEMBL-Plants: tr|I3SNL5|I3SNL5_LOTJA Annexin; Found in the gene: LotjaGi3g1v0062800 | 15 | ||
– | Annexin; TAIR: AT5G12380.1 annexin 8; Swiss-Prot: sp|P51074|ANX4_FRAAN Annexin-like protein RJ4; TrEMBL-Plants: tr|I3S6J0|I3S6J0_LOTJA Annexin; Found in the gene: LotjaGi3g1v0062900 | 15 | ||
– | Annexin; TAIR: AT5G12380.1 annexin 8; Swiss-Prot: sp|P51074|ANX4_FRAAN Annexin-like protein RJ4; TrEMBL-Plants: tr|I3S6J0|I3S6J0_LOTJA Annexin; Found in the gene: LotjaGi3g1v0062900 | 15 | ||
– | Annexin; TAIR: AT5G12380.1 annexin 8; Swiss-Prot: sp|P51074|ANX4_FRAAN Annexin-like protein RJ4; TrEMBL-Plants: tr|I3S6J0|I3S6J0_LOTJA Annexin; Found in the gene: LotjaGi3g1v0062900 | 13 | ||
– | Annexin; TAIR: AT5G12380.1 annexin 8; Swiss-Prot: sp|P51074|ANX4_FRAAN Annexin-like protein RJ4; TrEMBL-Plants: tr|I3S6J0|I3S6J0_LOTJA Annexin; Found in the gene: LotjaGi3g1v0062900 | 13 | ||
– | Annexin; TAIR: AT5G12380.1 annexin 8; Swiss-Prot: sp|P51074|ANX4_FRAAN Annexin-like protein RJ4; TrEMBL-Plants: tr|B7FJY0|B7FJY0_MEDTR Annexin; Found in the gene: LotjaGi3g1v0112700 | 15 | ||
– | Annexin; TAIR: AT5G12380.1 annexin 8; Swiss-Prot: sp|P51074|ANX4_FRAAN Annexin-like protein RJ4; TrEMBL-Plants: tr|B7FJY0|B7FJY0_MEDTR Annexin; Found in the gene: LotjaGi3g1v0112700 | 15 | ||
– | Annexin; TAIR: AT5G12380.1 annexin 8; Swiss-Prot: sp|P51074|ANX4_FRAAN Annexin-like protein RJ4; TrEMBL-Plants: tr|B7FJY0|B7FJY0_MEDTR Annexin; Found in the gene: LotjaGi3g1v0112700 | 14 | ||
– | Annexin; TAIR: AT5G12380.1 annexin 8; Swiss-Prot: sp|P51074|ANX4_FRAAN Annexin-like protein RJ4; TrEMBL-Plants: tr|I1LLC0|I1LLC0_SOYBN Annexin; Found in the gene: LotjaGi3g1v0112700 | 13 | ||
– | Annexin; TAIR: AT5G12380.1 annexin 8; Swiss-Prot: sp|P51074|ANX4_FRAAN Annexin-like protein RJ4; TrEMBL-Plants: tr|I1LLC0|I1LLC0_SOYBN Annexin; Found in the gene: LotjaGi3g1v0112700 | 13 | ||
– | Annexin; TAIR: AT5G12380.1 annexin 8; Swiss-Prot: sp|P51074|ANX4_FRAAN Annexin-like protein RJ4; TrEMBL-Plants: tr|A0A0R4J363|A0A0R4J363_SOYBN Annexin; Found in the gene: LotjaGi3g1v0112800 | 16 | ||
– | Annexin; TAIR: AT5G12380.1 annexin 8; Swiss-Prot: sp|P51074|ANX4_FRAAN Annexin-like protein RJ4; TrEMBL-Plants: tr|I1JWG6|I1JWG6_SOYBN Annexin; Found in the gene: LotjaGi3g1v0112800 | 15 | ||
– | Annexin; TAIR: AT5G65020.1 annexin 2; Swiss-Prot: sp|Q9XEE2|ANXD2_ARATH Annexin D2; TrEMBL-Plants: tr|I3RZY7|I3RZY7_LOTJA Annexin; Found in the gene: LotjaGi4g1v0397700 | 15 | ||
– | Annexin; TAIR: AT1G68090.1 annexin 5; Swiss-Prot: sp|Q9C9X3|ANXD5_ARATH Annexin D5; TrEMBL-Plants: tr|A0A0R0IHL7|A0A0R0IHL7_SOYBN Annexin; Found in the gene: LotjaGi4g1v0465600 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
SSF47874 | SUPERFAMILY | 1 | 2.63 |