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IPR019448 is a NT-type C2 domain.
<p>The C2 domain is one of the most prevalent eukaryotic lipid-binding domains deployed in diverse functional contexts. Many C2 domains bind directly to membrane lipids and display a wide range of lipid selectivity, with preference for anionic phosphatidylserine (PS) and phosphatidylinositol-phosphates (PIPs).</p> <p>Despite their limited sequence similarity, all C2 domains contain at their core a compact β-sandwich composed of two four-stranded β sheets with highly variable inter-strand regions that might contain one or more alpha- helices.</p> <p>The NT-type C2 domain shows a diverse range of domain architectures but it is nearly always found at the N-termini of proteins that contain it. Hence, it has been named the N-terminal C2 (NT-C2) family. It is typically coupled with a coiled-coil domain, that could mediate di/oligo-merization and the DIL (Dilute) domain. It is also coupled with the Calponin homology (CH) domain in EHBP1 proteins, Filamin/ABP280 repeats and Mg2+ transporter MgtE N-terminal domain in proteins from chlorophyte algae such as Micromonas and Ostreococcus tauri. Thus, a common theme across the NT-type C2 domain proteins is the combination to several different domains with microfilament-binding or actin-related roles (i.e. such as CH, DIL, and Filamin). Other conserved groups of the NT-type C2 proteins prototyped by EEIG1, PMI1, and SYNC1 have their own distinct C- terminal conserved extensions that are restricted to these groups and might mediate specific interactions. The primary function of the NT-type C2 domain appears to be the linking of actin/microfilament-binding adaptors to the membrane and to act as a link that tethers endosomal vesicles to the cytoskeleton in course of their intracellular trafficking [[cite:PUB00057260], [cite:PUB00088686]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Uncharacterized protein isoform 1 [Theobroma cacao] gi|508783082|gb|EOY30338.1| | 5 | ||
| – | F2E2.13 [Arabidopsis thaliana] gi|9280691|gb|AAF86560.1|AC069252_19 | 6 | ||
| – | F2E2.13 [Arabidopsis thaliana] gi|9280691|gb|AAF86560.1|AC069252_19 | 6 | ||
| – | F26K24.5 protein [Theobroma cacao] gi|508716626|gb|EOY08523.1| | 5 | ||
| – | Plastid movement impaired1 [Theobroma cacao] gi|508717238|gb|EOY09135.1| | 6 | ||
| – | PREDICTED: myosin-11-like [Cicer arietinum] gi|502159959|ref|XP_004511587.1| | 6 | ||
| – | PREDICTED: myosin-11-like [Cicer arietinum] gi|502159959|ref|XP_004511587.1| | 6 | ||
| – | Uncharacterized protein isoform 1 [Theobroma cacao] gi|508783082|gb|EOY30338.1| | 11 | ||
| – | PREDICTED: myosin-11-like isoform X1 [Cicer arietinum] gi|502139425|ref|XP_004503761.1| | 5 | ||
| – | PREDICTED: myosin-11-like isoform X1 [Cicer arietinum] gi|502139425|ref|XP_004503761.1| | 5 | ||
| – | Plastid movement impaired1 [Theobroma cacao] gi|508717238|gb|EOY09135.1| | 6 | ||
| – | PREDICTED: myosin-9-like [Cicer arietinum] gi|502182590|ref|XP_004516963.1| | 6 | ||
| – | F26K24.5 protein [Theobroma cacao] gi|508716626|gb|EOY08523.1| | 6 | ||
| – | F26K24.5 protein [Theobroma cacao] gi|508716626|gb|EOY08523.1| | 9 | ||
| – | Hyaluronan mediated motility receptor-like protein [Medicago truncatula] gi|358348662|ref|XP_003638363.1| | 11 | ||
| – | Uncharacterized protein isoform 1 [Theobroma cacao] gi|508783082|gb|EOY30338.1| | 9 | ||
| – | F-box and Leucine Rich Repeat domains containing protein, putative isoform 1; TAIR: AT1G22060.1 sporulation-specific protein; Swiss-Prot: sp|Q6P6L0|FIL1L_MOUSE Filamin A-interacting protein 1-like; TrEMBL-Plants: tr|M5Y4E1|M5Y4E1_PRUPE Uncharacterized protein; Found in the gene: LotjaGi1g1v0247500_LC | 7 | ||
| – | Nucleolar-like protein; TAIR: AT3G01810.1 EEIG1/EHBP1 protein amino-terminal domain protein; Swiss-Prot: sp|P54696|MYOH_DICDI Myosin-H heavy chain; TrEMBL-Plants: tr|K7MXD2|K7MXD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0622000 | 8 | ||
| – | EEIG1/EHBP1 N-terminal domain-containing protein; TAIR: AT3G11760.1 structural maintenance of chromosomes flexible hinge domain protein; Swiss-Prot: sp|Q9NYF8|BCLF1_HUMAN Bcl-2-associated transcription factor 1; TrEMBL-Plants: tr|I1NAV7|I1NAV7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0739000 | 6 | ||
| – | Protein PLASTID MOVEMENT IMPAIRED 1; TAIR: AT1G42550.1 plastid movement impaired1; Swiss-Prot: sp|Q9C8E6|PMI1_ARATH Protein PLASTID MOVEMENT IMPAIRED 1; TrEMBL-Plants: tr|K7LE44|K7LE44_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0199800 | 8 | ||
| – | Myosin heavy chain-like protein; TAIR: AT1G63300.1 Myosin heavy chain-related protein; Swiss-Prot: sp|P02566|MYO4_CAEEL Myosin-4; TrEMBL-Plants: tr|A0A0B2QVR4|A0A0B2QVR4_GLYSO Uncharacterized protein; Found in the gene: LotjaGi2g1v0432800 | 8 | ||
| – | EEIG1/EHBP1 protein amino-terminal domain protein; TAIR: AT5G20610.1 EEIG1/EHBP1 protein amino-terminal domain protein; Swiss-Prot: sp|F4K5K6|PMIR1_ARATH Protein PLASTID MOVEMENT IMPAIRED 1-RELATED 1; TrEMBL-Plants: tr|A0A1J7J0U7|A0A1J7J0U7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0327800 | 16 | ||
| – | Myosin heavy chain-like protein; TAIR: AT1G63300.1 Myosin heavy chain-related protein; Swiss-Prot: sp|Q21313|EPI1_CAEEL Laminin-like protein epi-1; TrEMBL-Plants: tr|A0A0B2QAM3|A0A0B2QAM3_GLYSO Uncharacterized protein; Found in the gene: LotjaGi4g1v0424400 | 7 | ||
| – | Plastid movement impaired protein; TAIR: AT1G42550.1 plastid movement impaired1; Swiss-Prot: sp|Q9C8E6|PMI1_ARATH Protein PLASTID MOVEMENT IMPAIRED 1; TrEMBL-Plants: tr|G7LD87|G7LD87_MEDTR Plastid movement impaired protein; Found in the gene: LotjaGi4g1v0461600 | 7 | ||
| – | Protein plastid movement impaired 1-related 1; TAIR: AT5G26160.1 light-independent protochlorophyllide reductase subunit; Swiss-Prot: sp|Q7Y219|PMIR2_ARATH Protein PLASTID MOVEMENT IMPAIRED 1-RELATED 2; TrEMBL-Plants: tr|A0A0B2P9D0|A0A0B2P9D0_GLYSO Uncharacterized protein; Found in the gene: LotjaGi5g1v0047900 | 8 | ||
| – | Myosin heavy chain-related protein, putative isoform 1; TAIR: AT1G22060.1 sporulation-specific protein; Swiss-Prot: sp|Q13948|CASP_HUMAN Protein CASP; TrEMBL-Plants: tr|A0A0B2RXA4|A0A0B2RXA4_GLYSO Uncharacterized protein; Found in the gene: LotjaGi5g1v0086600 | 7 | ||
| – | EEIG1/EHBP1 protein amino-terminal domain protein; TAIR: AT3G11760.1 structural maintenance of chromosomes flexible hinge domain protein; TrEMBL-Plants: tr|I1L9M1|I1L9M1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0107100 | 6 | ||
| – | EEIG1/EHBP1 protein amino-terminal domain protein; TAIR: AT3G11760.1 structural maintenance of chromosomes flexible hinge domain protein; TrEMBL-Plants: tr|I1L9M1|I1L9M1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0107100 | 6 | ||
| – | Nucleolar-like protein; TAIR: AT5G43230.1 EEIG1/EHBP1 protein amino-terminal domain protein; Swiss-Prot: sp|P54696|MYOH_DICDI Myosin-H heavy chain; TrEMBL-Plants: tr|K7LK51|K7LK51_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0190000 | 6 | ||
| – | Myosin heavy chain-like protein, putative; TAIR: AT5G52280.1 Myosin heavy chain-related protein; Swiss-Prot: sp|P08799|MYS2_DICDI Myosin-2 heavy chain; TrEMBL-Plants: tr|B3RH40|B3RH40_MEDTR Myosin heavy chain-like protein, putative; Found in the gene: LotjaGi5g1v0253300 | 6 | ||
| – | Myosin heavy chain-like protein; TAIR: AT5G52280.1 Myosin heavy chain-related protein; Swiss-Prot: sp|P11046|LAMB1_DROME Laminin subunit beta-1; TrEMBL-Plants: tr|I1LDS0|I1LDS0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0301300 | 12 | ||
| – | EEIG1/EHBP1 protein amino-terminal domain protein; TAIR: AT5G20610.1 EEIG1/EHBP1 protein amino-terminal domain protein; Swiss-Prot: sp|F4K5K6|PMIR1_ARATH Protein PLASTID MOVEMENT IMPAIRED 1-RELATED 1; TrEMBL-Plants: tr|A0A072V6S3|A0A072V6S3_MEDTR EEIG1/EHBP1 protein amino-terminal domain protein; Found in the gene: LotjaGi6g1v0227600 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 3.13 |