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IPR019495 is a Exosome complex component CSL4, C-terminal.
<p>Exosome is a complex of 3' --> 5' exoribonucleases that play a major role in diverse RNA processing and degradation pathways. The eukaryotic exosome complex contains 9 proteins. Six RNase PH domain containing proteins (Rrp41, Rrp42, Rrp43, Rrp45, Rrp46, and Mtr3) form a catalytic ring, three RNA binding domain containing proteins (Rrp4,Rrp40, and Csl4) bind on top of the ring [[cite:PUB00035569]].</p> <p>This entry represents the C-terminal domain of the exosome complex component CSL4 (also known as EXOSC1). CSL4 does not have exonuclease activity, but are required for the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and for mRNA decay [[cite:PUB00045433], [cite:PUB00045434]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Exosome (RNase complex) | A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. | ||
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Nucleic acid-binding, OB-fold-like protein isoform 1 [Theobroma cacao] gi|508718921|gb|EOY10818.1| | 13 | ||
| – | Exosome complex component CSL4; TAIR: AT5G38890.1 Nucleic acid-binding, OB-fold-like protein; Swiss-Prot: sp|Q9DAA6|EXOS1_MOUSE Exosome complex component CSL4; TrEMBL-Plants: tr|K7LJV1|K7LJV1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0205900 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |