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IPR019585 is a 26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1.
<p>This entry includes 26S proteasome regulatory subunit Rpn7 and COP9 signalosome complex subunit 1 (Csn1) and fungal CSN11.</p> <p>The 26S proteasome plays a major role in ATP-dependent degradation of ubiquitinated proteins. Substrate specificity is conferred by the regulatory particle (RP), which can dissociate into stable lid and base subcomplexes. The regulatory subunit RPN7 is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity [[cite:PUB00045323]].</p> <p>The COP9 signalosome is a conserved protein complex composed of eight subunits, where individual subunits of the complex have been linked to various signal transduction pathways leading to gene expression and cell cycle control [[cite:PUB00045324]]. The overall organisation and the amino acid sequences of the COP9 signalosome subunits resemble the lid subcomplex of the 19 S regulatory particle for the 26 S proteasome [[cite:PUB00034668]]. COP9 subunit 1 (CSN1 or GPS1) of the COP9 complex is an essential subunit of the complex with regard to both structural integrity and functionality. The N-terminal region of subunit 1 (CSN1-N) can inhibit c-fos expression from either a transfected template or a chromosomal transgene (fos-lacZ), and may contain the activity domain that confers most of the repression functions of CSN1. The C-terminal region of subunit 1 (CSN1-C) allows integration of the protein into the COP9 signalosome.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: COP9 signalosome complex subunit 1-like [Glycine max] gi|356505043|ref|XP_003521302.1| | 13 | ||
| – | PREDICTED: probable 26S proteasome non-ATPase regulatory subunit 6-like isoform X2 [Cicer arietinum] gi|502176264|ref|XP_004515835.1| | 12 | ||
| – | PREDICTED: probable 26S proteasome non-ATPase regulatory subunit 6-like isoform X2 [Cicer arietinum] gi|502176264|ref|XP_004515835.1| | 12 | ||
| – | PREDICTED: probable 26S proteasome non-ATPase regulatory subunit 6-like isoform X2 [Cicer arietinum] gi|502176264|ref|XP_004515835.1| | 14 | ||
| – | COP9 signalosome complex subunit 1; TAIR: AT3G61140.1 COP9 signalosome complex subunit 1; Swiss-Prot: sp|P45432|CSN1_ARATH COP9 signalosome complex subunit 1; TrEMBL-Plants: tr|I1JKE3|I1JKE3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0376700 | 14 | ||
| – | 26S proteasome non-ATPase regulatory subunit; TAIR: AT4G24820.1 26S proteasome regulatory subunit Rpn7; Swiss-Prot: sp|Q93Y35|PSMD6_ARATH 26S proteasome non-ATPase regulatory subunit 6 homolog; TrEMBL-Plants: tr|A0A151TE54|A0A151TE54_CAJCA Putative 26S proteasome non-ATPase regulatory subunit 6; Found in the gene: LotjaGi4g1v0224400 | 13 | ||
| – | 26S proteasome non-ATPase regulatory subunit; TAIR: AT4G24820.1 26S proteasome regulatory subunit Rpn7; Swiss-Prot: sp|Q93Y35|PSMD6_ARATH 26S proteasome non-ATPase regulatory subunit 6 homolog; TrEMBL-Plants: tr|A0A151TE54|A0A151TE54_CAJCA Putative 26S proteasome non-ATPase regulatory subunit 6; Found in the gene: LotjaGi4g1v0224400 | 13 | ||
| – | 26S proteasome non-ATPase regulatory subunit; TAIR: AT4G24820.1 26S proteasome regulatory subunit Rpn7; Swiss-Prot: sp|Q93Y35|PSMD6_ARATH 26S proteasome non-ATPase regulatory subunit 6 homolog; TrEMBL-Plants: tr|A0A151TE54|A0A151TE54_CAJCA Putative 26S proteasome non-ATPase regulatory subunit 6; Found in the gene: LotjaGi4g1v0224400 | 13 | ||
| – | 26S proteasome non-ATPase regulatory subunit; TAIR: AT4G24820.1 26S proteasome regulatory subunit Rpn7; Swiss-Prot: sp|Q93Y35|PSMD6_ARATH 26S proteasome non-ATPase regulatory subunit 6 homolog; TrEMBL-Plants: tr|V7CBH3|V7CBH3_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0017400 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF46785 | SUPERFAMILY | 1 | 11.11 |