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IPR020560

Description

IPR020560 is a Phosphoribosylglycinamide synthetase, C-domain.

<p>Phosphoribosylglycinamide synthetase ([ec:6.3.4.13]) (GARS) (phosphoribosylamine glycine ligase) [[cite:PUB00002527]] catalyses the second step in the<i>de novo</i>biosynthesis of purine. The reaction catalysed by phosphoribosylglycinamide synthetase is the ATP-dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide:</p> <p> <reaction> ATP + 5-phosphoribosylamine + glycine = ADP + P<sub>i</sub>+ 5'-phosphoribosylglycinamide </reaction> </p> <p>In bacteria, GARS is a monofunctional enzyme (encoded by the purD gene). In yeast, GARS is part of a bifunctional enzyme (encoded by the ADE5,7 gene) in conjunction with phosphoribosylformylglycinamidine cyclo-ligase (AIRS) [[cite:PUB00075625]]. In higher eukaryotes, GARS is part of a trifunctional enzyme in conjunction with AIRS and with phosphoribosylglycinamide formyltransferase (GART), forming GARS-AIRS-GART [[cite:PUB00075622]].</p> <p>This entry represents the C-domain, which is related to the C-terminal domain of biotin carboxylase/carbamoyl phosphate synthetase ([interpro:IPR005480]).</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Phosphoribosylamine-glycine ligase activity Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate.
Biological process Purine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
PREDICTED: phosphoribosylamine--glycine ligase, chloroplastic-like isoform X2 [Cicer arietinum] gi|502123844|ref|XP_004498282.1| 28
Phosphoribosylamine-glycine ligase; TAIR: AT1G09830.1 Glycinamide ribonucleotide (GAR) synthetase; Swiss-Prot: sp|P52420|PUR2_ARATH Phosphoribosylamine--glycine ligase, chloroplastic; TrEMBL-Plants: tr|K7LJM6|K7LJM6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0354900 28

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR00877 TIGRFAM 1 50.00