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IPR020561

Source: InterPro

Description

IPR020561 is a Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain.

<p>Phosphoribosylglycinamide synthetase ([ec:6.3.4.13]) (GARS) (phosphoribosylamine glycine ligase) [[cite:PUB00002527]] catalyses the second step in the<i>de novo</i>biosynthesis of purine. The reaction catalysed by phosphoribosylglycinamide synthetase is the ATP-dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide:</p> <p> <reaction> ATP + 5-phosphoribosylamine + glycine = ADP + P<sub>i</sub>+ 5'-phosphoribosylglycinamide </reaction> </p> <p>In bacteria, GARS is a monofunctional enzyme (encoded by the purD gene). In yeast, GARS is part of a bifunctional enzyme (encoded by the ADE5,7 gene) in conjunction with phosphoribosylformylglycinamidine cyclo-ligase (AIRS) [[cite:PUB00075625]]. In higher eukaryotes, GARS is part of a trifunctional enzyme in conjunction with AIRS and with phosphoribosylglycinamide formyltransferase (GART), forming GARS-AIRS-GART [[cite:PUB00075622]].</p> <p>This entry represents the A-domain of the enzyme, and is related to the ATP-grasp domain of biotin carboxylase/carbamoyl phosphate synthetase.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj5g3v2263910.1
– PREDICTED: phosphoribosylamine--glycine ligase, chloroplastic-like isoform X2 [Cicer arietinum] gi|502123844|ref|XP_004498282.1|
Domains
28
LotjaGi5g1v0354900.1
– Phosphoribosylamine-glycine ligase; TAIR: AT1G09830.1 Glycinamide ribonucleotide (GAR) synthetase; Swiss-Prot: sp|P52420|PUR2_ARATH Phosphoribosylamine--glycine ligase, chloroplastic; TrEMBL-Plants: tr|K7LJM6|K7LJM6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0354900
Domains
28

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR00877 TIGRFAM 1 50.00