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IPR020904 is a Short-chain dehydrogenase/reductase, conserved site.
<p>The short-chain dehydrogenases/reductases family (SDR) [[cite:PUB00000419], [cite:PUB00075490]] is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases. As the first member of this family to be characterised was Drosophila alcohol dehydrogenase, this family used to be called [[cite:PUB00001371], [cite:PUB00001399], [cite:PUB00001408]] 'insect-type', or 'short-chain' alcohol dehydrogenases. Most members of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases possess at least 2 domains [[cite:PUB00004592]], the first binding the coenzyme, often NAD, and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis. Little sequence similarity has been found in the coenzyme binding domain although there is a large degree of structural similarity, and it has therefore been suggested that the structure of dehydrogenases has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains [[cite:PUB00004592]].</p> <p>This entry contains a signature pattern for this family of proteins which covers one of the best conserved regions. It includes two perfectly conserved residues, a tyrosine and a lysine. The tyrosine residue participates in the catalytic mechanism.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: chlorophyll(ide) b reductase NOL, chloroplastic-like [Glycine max] gi|356556680|ref|XP_003546651.1| | 19 | ||
| – | Short-chain alcohol dehydrogenase [Medicago truncatula] gi|357497085|ref|XP_003618831.1| | 12 | ||
| – | PREDICTED: 3-oxoacyl-[acyl]-carrier-protein] gi|502135409|ref|XP_004502323.1| | 11 | ||
| – | Glucose and ribitol dehydrogenase-like protein [Medicago truncatula] gi|357480215|ref|XP_003610393.1| | 12 | ||
| – | PREDICTED: momilactone A synthase-like [Glycine max] gi|356508598|ref|XP_003523042.1| | 10 | ||
| – | PREDICTED: (+)-neomenthol dehydrogenase-like [Cicer arietinum] gi|502157292|ref|XP_004510823.1| | 9 | ||
| – | PREDICTED: 3-oxoacyl-[acyl]-carrier-protein] gi|356500296|ref|XP_003518969.1| | 12 | ||
| – | Retinol dehydrogenase [Medicago truncatula] gi|357463463|ref|XP_003602013.1| | 13 | ||
| – | PREDICTED: momilactone A synthase-like [Glycine max] gi|356508598|ref|XP_003523042.1| | 11 | ||
| – | PREDICTED: dehydrogenase/reductase SDR family member 7-like isoform X1 [Cicer arietinum] gi|502105676|ref|XP_004492860.1| | 10 | ||
| – | PREDICTED: short-chain dehydrogenase reductase 2a-like isoform X1 [Cicer arietinum] gi|502100886|ref|XP_004491766.1| | 11 | ||
| – | PREDICTED: momilactone A synthase-like [Cicer arietinum] gi|502112050|ref|XP_004494228.1| | 12 | ||
| – | PREDICTED: momilactone A synthase-like [Glycine max] gi|356570883|ref|XP_003553613.1| | 11 | ||
| – | PREDICTED: tropinone reductase-like 3-like [Cicer arietinum] gi|502149759|ref|XP_004507653.1| | 11 | ||
| – | PREDICTED: momilactone A synthase-like [Glycine max] gi|356542776|ref|XP_003539841.1| | 11 | ||
| – | NAD(P)-binding Rossmann-fold superfamily protein isoform 1 [Theobroma cacao] gi|508778465|gb|EOY25721.1| | 12 | ||
| – | 15-hydroxyprostaglandin dehydrogenase [Medicago truncatula] gi|357475423|ref|XP_003607997.1| | 29 | ||
| – | 15-hydroxyprostaglandin dehydrogenase [Medicago truncatula] gi|357475423|ref|XP_003607997.1| | 24 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: hydroxysteroid 11-beta-dehydrogenase 1-like protein-like [Glycine max] gi|356511514|ref|XP_003524470.1| | 11 | ||
| – | PREDICTED: dehydrogenase/reductase SDR family protein 7-like [Cicer arietinum] gi|502139353|ref|XP_004503736.1| | 15 | ||
| – | Glucose and ribitol dehydrogenase [Medicago truncatula] gi|357441633|ref|XP_003591094.1| | 11 | ||
| – | PREDICTED: inactive hydroxysteroid dehydrogenase-like protein 1-like [Glycine max] gi|356567433|ref|XP_003551924.1| | 17 | ||
| – | Dihydromonapterin reductase, NADPH-dependent [Serratia marcescens WW4] gi|448242335|ref|YP_007406388.1| | 9 | ||
| – | PREDICTED: tropinone reductase homolog At1g07440-like [Cicer arietinum] gi|502137748|ref|XP_004503172.1| | 11 | ||
| – | PREDICTED: tropinone reductase homolog At1g07440-like [Cicer arietinum] gi|502137752|ref|XP_004503173.1| | 16 | ||
| – | PREDICTED: 3-ketodihydrosphingosine reductase-like isoform 2 [Glycine max] gi|356548985|ref|XP_003542879.1| | 16 | ||
| – | Short-chain dehydrogenase/reductase family protein; TAIR: AT1G54870.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9FZ42|GRDH1_ARATH Glucose and ribitol dehydrogenase homolog 1; TrEMBL-Plants: tr|I3SGZ5|I3SGZ5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0093600 | 11 | ||
| – | Short-chain dehydrogenase/reductase family protein; TAIR: AT1G54870.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9FZ42|GRDH1_ARATH Glucose and ribitol dehydrogenase homolog 1; TrEMBL-Plants: tr|I3SGZ5|I3SGZ5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0093900 | 11 | ||
| – | 3-oxoacyl-reductase; TAIR: AT3G55290.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q93X62|FABG1_BRANA 3-oxoacyl-[acyl]-carrier-protein] reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A0R0L6W1|A0A0R0L6W1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0211600 | 12 | ||
| – | 3-oxoacyl-reductase; TAIR: AT3G55290.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q93X62|FABG1_BRANA 3-oxoacyl-[acyl]-carrier-protein] reductase 1, chloroplastic; TrEMBL-Plants: tr|A0A0R0L6W1|A0A0R0L6W1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0211600 | 12 | ||
| – | Short-chain dehydrogenase/reductase; TAIR: AT2G47140.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q5C9I9|ISPD_MENPI (-)-isopiperitenol/(-)-carveol dehydrogenase, mitochondrial; TrEMBL-Plants: tr|G7KNM6|G7KNM6_MEDTR Short-chain alcohol dehydrogenase; Found in the gene: LotjaGi1g1v0214700 | 11 | ||
| – | Dehydrogenase/reductase SDR family protein; TAIR: AT3G03330.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9Y394|DHRS7_HUMAN Dehydrogenase/reductase SDR family member 7; TrEMBL-Plants: tr|I3SNJ5|I3SNJ5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0487500 | 14 | ||
| – | Short-chain dehydrogenase/reductase; TAIR: AT4G03140.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q94KL7|SILD_FORIN Secoisolariciresinol dehydrogenase; TrEMBL-Plants: tr|A0A0S3RZE8|A0A0S3RZE8_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0734700 | 12 | ||
| – | Short-chain dehydrogenase/reductase; TAIR: AT1G52340.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q94KL7|SILD_FORIN Secoisolariciresinol dehydrogenase; TrEMBL-Plants: tr|A0A0B2P3E4|A0A0B2P3E4_GLYSO Momilactone A synthase; Found in the gene: LotjaGi1g1v0734700 | 11 | ||
| – | Short-chain dehydrogenase-reductase; TAIR: AT3G51680.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q94KL7|SILD_FORIN Secoisolariciresinol dehydrogenase; TrEMBL-Plants: tr|V7D0A1|V7D0A1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0734800 | 11 | ||
| – | Dehydrogenase; TAIR: AT1G54870.2 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9FZ42|GRDH1_ARATH Glucose and ribitol dehydrogenase homolog 1; TrEMBL-Plants: tr|I3SGZ5|I3SGZ5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0774200 | 13 | ||
| – | Dehydrogenase/reductase SDR family protein; TAIR: AT4G10020.1 hydroxysteroid dehydrogenase 5; Swiss-Prot: sp|Q9T0G0|HSD5_ARATH 11-beta-hydroxysteroid dehydrogenase-like 5; TrEMBL-Plants: tr|G7K984|G7K984_MEDTR Corticosteroid 11-beta-dehydrogenase; Found in the gene: LotjaGi2g1v0444100 | 10 | ||
| – | Dehydrogenase/reductase SDR family protein; TAIR: AT4G10020.1 hydroxysteroid dehydrogenase 5; Swiss-Prot: sp|Q9T0G0|HSD5_ARATH 11-beta-hydroxysteroid dehydrogenase-like 5; TrEMBL-Plants: tr|C6T871|C6T871_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi2g1v0444100 | 10 | ||
| – | Short chain dehydrogenase/reductase; TAIR: AT3G61220.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9M2E2|SDR1_ARATH (+)-neomenthol dehydrogenase; TrEMBL-Plants: tr|I1JKC0|I1JKC0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0379800 | 12 | ||
| – | Short-chain dehydrogenase/reductase family protein; TAIR: AT3G61220.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9M2E2|SDR1_ARATH (+)-neomenthol dehydrogenase; TrEMBL-Plants: tr|I3SA17|I3SA17_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0379900 | 12 | ||
| – | Short-chain dehydrogenase/reductase family protein; TAIR: AT3G61220.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9M2E2|SDR1_ARATH (+)-neomenthol dehydrogenase; TrEMBL-Plants: tr|I3SA17|I3SA17_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0379900 | 12 | ||
| – | Short-chain dehydrogenase/reductase; TAIR: AT1G52340.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q94KL7|SILD_FORIN Secoisolariciresinol dehydrogenase; TrEMBL-Plants: tr|A0A0S3SC50|A0A0S3SC50_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0474200 | 11 | ||
| – | Short-chain dehydrogenase/reductase; TAIR: AT3G51680.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q94KL7|SILD_FORIN Secoisolariciresinol dehydrogenase; TrEMBL-Plants: tr|A0A0R0HCQ2|A0A0R0HCQ2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0474400 | 12 | ||
| – | Short-chain dehydrogenase/reductase; TAIR: AT3G51680.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q94KL7|SILD_FORIN Secoisolariciresinol dehydrogenase; TrEMBL-Plants: tr|A0A0R0HCQ2|A0A0R0HCQ2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0474400 | 12 | ||
| – | Tropinone reductase like; TAIR: AT2G29150.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9ZW03|TRNH3_ARATH Tropinone reductase homolog At2g29150; TrEMBL-Plants: tr|I3S2B2|I3S2B2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0490800 | 12 | ||
| – | Tropinone reductase like; TAIR: AT2G29150.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9ZW03|TRNH3_ARATH Tropinone reductase homolog At2g29150; TrEMBL-Plants: tr|I3SD52|I3SD52_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0491000 | 11 | ||
| – | Dehydrogenase/reductase SDR family protein; TAIR: AT1G10310.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9SY73|PTALR_ARATH NADPH-dependent pterin aldehyde reductase; TrEMBL-Plants: tr|A0A072V3L6|A0A072V3L6_MEDTR Enoyl-(Acyl carrier) reductase; Found in the gene: LotjaGi4g1v0001400 | 12 | ||
| – | Dehydrogenase/reductase SDR family member 4; TAIR: AT4G05530.1 indole-3-butyric acid response 1; Swiss-Prot: sp|H9BFQ2|TPRL3_ERYCB Tropinone reductase-like 3; TrEMBL-Plants: tr|I3SY67|I3SY67_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0009600 | 11 | ||
| – | Dehydrogenase/reductase SDR family member 4; TAIR: AT4G05530.1 indole-3-butyric acid response 1; Swiss-Prot: sp|H9BFQ2|TPRL3_ERYCB Tropinone reductase-like 3; TrEMBL-Plants: tr|I3SY67|I3SY67_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0009600 | 11 | ||
| – | Zinc-binding dehydrogenase family protein; TAIR: AT1G49670.1 ARP protein (REF); Swiss-Prot: sp|Q8BGC4|PTGR3_MOUSE Prostaglandin reductase-3; TrEMBL-Plants: tr|G7JLA7|G7JLA7_MEDTR Alcohol dehydrogenase zinc-binding domain protein; Found in the gene: LotjaGi4g1v0072900 | 28 | ||
| – | Short-chain dehydrogenase/reductase; TAIR: AT2G47140.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q5C9I9|ISPD_MENPI (-)-isopiperitenol/(-)-carveol dehydrogenase, mitochondrial; TrEMBL-Plants: tr|V7B017|V7B017_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0186200 | 11 | ||
| – | Dehydrogenase; TAIR: AT1G54870.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q5KTS5|GRDH_DAUCA Glucose and ribitol dehydrogenase; TrEMBL-Plants: tr|G7JI03|G7JI03_MEDTR Short-chain dehydrogenase/reductase; Found in the gene: LotjaGi4g1v0353000 | 13 | ||
| – | Short-chain dehydrogenase/reductase; TAIR: AT1G54870.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9FZ42|GRDH1_ARATH Glucose and ribitol dehydrogenase homolog 1; TrEMBL-Plants: tr|C6TKH0|C6TKH0_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi4g1v0353000 | 11 | ||
| – | Dehydrogenase/reductase SDR family protein; TAIR: AT5G50600.1 hydroxysteroid dehydrogenase 1; Swiss-Prot: sp|P0DKC5|HSD1A_ARATH 11-beta-hydroxysteroid dehydrogenase 1A; TrEMBL-Plants: tr|A0A1J7GIP7|A0A1J7GIP7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0418700 | 15 | ||
| – | Short-chain dehydrogenase/reductase family protein; TAIR: AT1G54870.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9FZ42|GRDH1_ARATH Glucose and ribitol dehydrogenase homolog 1; TrEMBL-Plants: tr|I3SYP3|I3SYP3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0220100 | 13 | ||
| – | Short-chain dehydrogenase/reductase family protein; TAIR: AT1G54870.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9FZ42|GRDH1_ARATH Glucose and ribitol dehydrogenase homolog 1; TrEMBL-Plants: tr|I3SYP3|I3SYP3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0220100 | 11 | ||
| – | Short-chain dehydrogenase/reductase family protein; TAIR: AT1G54870.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9FZ42|GRDH1_ARATH Glucose and ribitol dehydrogenase homolog 1; TrEMBL-Plants: tr|I3SYP3|I3SYP3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0220100 | 13 | ||
| – | Tropinone reductase, putative; TAIR: AT5G06060.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9LHT0|TRNHF_ARATH Tropinone reductase homolog At5g06060; TrEMBL-Plants: tr|A0A103YDB1|A0A103YDB1_CYNCS Uncharacterized protein; Found in the gene: LotjaGi6g1v0064500 | 12 | ||
| – | Tropinone reductase like; TAIR: AT5G06060.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9LHT0|TRNHF_ARATH Tropinone reductase homolog At5g06060; TrEMBL-Plants: tr|A0A072UY64|A0A072UY64_MEDTR NAD(P)-binding rossmann-fold protein; Found in the gene: LotjaGi6g1v0064500 | 11 | ||
| – | Tropinone reductase like; TAIR: AT5G06060.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9LHT0|TRNHF_ARATH Tropinone reductase homolog At5g06060; TrEMBL-Plants: tr|I3SI52|I3SI52_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0064600 | 12 | ||
| – | Short-chain dehydrogenase/reductase family protein; TAIR: AT5G10050.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q09851|AYR1_SCHPO NADPH-dependent 1-acyldihydroxyacetone phosphate reductase; TrEMBL-Plants: tr|I3SB82|I3SB82_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0084700 | 13 | ||
| – | Short-chain dehydrogenase/reductase; TAIR: AT1G67730.1 beta-ketoacyl reductase 1; Swiss-Prot: sp|Q8L9C4|KCR1_ARATH Very-long-chain 3-oxoacyl-CoA reductase 1; TrEMBL-Plants: tr|A0A0B2QR74|A0A0B2QR74_GLYSO Inactive hydroxysteroid dehydrogenase-like protein 1; Found in the gene: LotjaGi6g1v0100700 | 17 | ||
| – | 3-oxoacyl-reductase; TAIR: AT1G24360.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q93X62|FABG1_BRANA 3-oxoacyl-[acyl]-carrier-protein] reductase 1, chloroplastic; TrEMBL-Plants: tr|I1LNB1|I1LNB1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0101200 | 15 | ||
| – | Dehydrogenase/reductase SDR family member 4; TAIR: AT4G05530.1 indole-3-butyric acid response 1; Swiss-Prot: sp|H9BFQ2|TPRL3_ERYCB Tropinone reductase-like 3; TrEMBL-Plants: tr|C6TLW3|C6TLW3_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi6g1v0288300 | 11 | ||
| – | 3-ketodihydrosphingosine reductase; TAIR: AT3G06060.2 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q0WRJ2|TC10A_ARATH 3-dehydrosphinganine reductase TSC10A; TrEMBL-Plants: tr|A0A1J7H225|A0A1J7H225_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0297000 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd08939 | CDD | 1 | 1.54 |