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IPR021841 is a Vacuolar protein 14, C-terminal Fig4-binding domain.
<p>Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes) [[cite:PUB00061897]]. This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system [[cite:PUB00061898]].</p> <p>This entry represents the C-terminal domain of Vac14, which binds to Fig4p.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: protein VAC14 homolog [Cicer arietinum] gi|502123772|ref|XP_004498253.1| | 14 | ||
| – | PREDICTED: protein VAC14 homolog [Glycine max] gi|356524533|ref|XP_003530883.1| | 14 | ||
| – | VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi2g1v0071300 | 14 | ||
| – | VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi2g1v0071300 | 13 | ||
| – | VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi2g1v0071300 | 14 | ||
| – | VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi2g1v0071300 | 13 | ||
| – | Protein VAC14 like; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A0B2Q990|A0A0B2Q990_GLYSO Protein VAC14 like; Found in the gene: LotjaGi4g1v0457000 | 14 | ||
| – | Protein VAC14 like; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A0B2Q990|A0A0B2Q990_GLYSO Protein VAC14 like; Found in the gene: LotjaGi4g1v0457000 | 13 | ||
| – | Protein VAC14 like; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A0B2Q990|A0A0B2Q990_GLYSO Protein VAC14 like; Found in the gene: LotjaGi4g1v0457000 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF48371 | SUPERFAMILY | 1 | 11.11 |