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IPR026825

Source: InterPro

Description

IPR026825 is a Vacuole morphology and inheritance protein 14.

<p>Vac14 is a component of the PI(3,5)P2 regulatory complex, which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) [[cite:PUB00061897]]. This complex is composed of Atg18, Fig4, Fab1, Vac14 and Vac7 in yeast. In mammals it consists of PIKfyve, FIG4 and VAC14. Fab1/PIKfyve (Fab1 in yeast and PIKfyve in mammals) is a kinase that converts PI(3)P into PI(3,5)P2 by phosphorylation at the 5-position; conversely Fig4 dephosphorylates PI(3,5)P2 back to PI(3)P. Vac14 is a scaffolding adaptor protein whose multimerisation is a prerequisite step for PI(3,5)P2 complex assembly and function [[cite:PUB00069629]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006661
Biological process Phosphatidylinositol biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
Subterm of
GO:0070772
Cellular component PAS complex A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.
Subterm of
Part of

Associated Lotus transcripts 20

Transcript Name Description Predicted domains Domain count
Lj0g3v0006439.1
– PREDICTED: protein VAC14 homolog [Cicer arietinum] gi|502123772|ref|XP_004498253.1|
Domains
14
Lj4g3v3113090.1
– PREDICTED: protein VAC14 homolog [Glycine max] gi|356524533|ref|XP_003530883.1|
Domains
14
LotjaGi1g1v0265500.1
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi1g1v0265500
Domains
8
LotjaGi1g1v0265500.2
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi1g1v0265500
Domains
5
LotjaGi1g1v0265500.3
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi1g1v0265500
Domains
8
LotjaGi1g1v0265500.4
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi1g1v0265500
Domains
5
LotjaGi1g1v0265500.5
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi1g1v0265500
Domains
5
LotjaGi2g1v0071300.1
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi2g1v0071300
Domains
14
LotjaGi2g1v0071300.2
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi2g1v0071300
Domains
13
LotjaGi2g1v0071300.3
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi2g1v0071300
Domains
14
LotjaGi2g1v0071300.4
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi2g1v0071300
Domains
13
LotjaGi2g1v0071300.5
– Protein VAC14 like; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|I1JDH1|I1JDH1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0071300
Domains
5
LotjaGi3g1v0222300.1
– Protein VAC14 like; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A067L1Z3|A0A067L1Z3_JATCU Uncharacterized protein; Found in the gene: LotjaGi3g1v0222300
Domains
5
LotjaGi3g1v0243000.1
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi3g1v0243000
Domains
7
LotjaGi4g1v0457000.1
– Protein VAC14 like; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A0B2Q990|A0A0B2Q990_GLYSO Protein VAC14 like; Found in the gene: LotjaGi4g1v0457000
Domains
14
LotjaGi4g1v0457000.2
– Protein VAC14 like; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A0B2Q990|A0A0B2Q990_GLYSO Protein VAC14 like; Found in the gene: LotjaGi4g1v0457000
Domains
13
LotjaGi4g1v0457000.3
– Protein VAC14 like; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A0B2Q990|A0A0B2Q990_GLYSO Protein VAC14 like; Found in the gene: LotjaGi4g1v0457000
Domains
13
LotjaGi4g1v0457000.5
– Protein VAC14 like; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A1J7GNE8|A0A1J7GNE8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0457000
Domains
5
LotjaGi6g1v0173200.1
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi6g1v0173200
Domains
7
LotjaGi6g1v0173200.2
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi6g1v0173200
Domains
7

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF48371 SUPERFAMILY 1 5.00