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IPR021891

Source: InterPro

Description

IPR021891 is a Telomerase ribonucleoprotein complex - RNA-binding domain.

<p>Telomeres in most organisms are comprised of tandem simple sequence repeats [[cite:PUB00053554]]. The total length of telomeric repeat sequence at each chromosome end is determined in a balance of sequence loss and sequence addition [[cite:PUB00053554]]. One major influence on telomere length is the enzyme telomerase [[cite:PUB00053554]]. It is a reverse transcriptase that adds these simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme [[cite:PUB00053554]]. The RNA binding domain of telomerase - TRBD - is made up of twelve α helices and two short β sheets [[cite:PUB00049245]]. How telomerase and associated regulatory factors physically interact and function with each other to maintain appropriate telomere length is poorly understood. It is known however that TRBD is involved in formation of the holoenzyme (which performs the telomere extension) in addition to recognition and binding of RNA [[cite:PUB00049245]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003964
Molecular function RNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj3g3v0839410.1
– PREDICTED: telomerase reverse transcriptase-like [Glycine max] gi|356555309|ref|XP_003545976.1|
Domains
14
Lj3g3v0839410.2
– Telomerase reverse transcriptase [Populus trichocarpa] gi|198075764|gb|ACH81294.1|
Domains
14
LotjaGi3g1v0123100.2
– Telomerase reverse transcriptase; TAIR: AT5G16850.1 telomerase reverse transcriptase; Swiss-Prot: sp|Q9SPU7|TERT_ARATH Telomerase reverse transcriptase; TrEMBL-Plants: tr|V7BV12|V7BV12_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0123100
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd01648 CDD 1 33.33