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IPR003545 is a Telomerase reverse transcriptase.
<p>Telomerase is an enzyme that, in certain cells, maintains the physical ends of chromosomes (telomeres) during replication. In somatic cells, replication of the lagging strand requires the continual presence of an RNA primer approximately 200 nucleotides upstream, which is complementary to the template strand. Since there is a region of DNA less than 200 base pairs from the end of the chromosome where this is not possible, the chromosome is continually shortened. However, there is a surplus of repetitive DNA at the ends, the telomeres, that protects against the erosion of gene-encoding DNA.<p>Telomerase is a ribonucleoprotein (RNP) that synthesises the telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. There are 2 protein components of the RNP: the catalytic subunit is known as telomerase reverse transcriptase (TERT). The reverse transcriptase domain is located in the C-terminal region of the TERT polypeptide and single amino acid substitutions in this region lead to telomere shortening and senescence [[cite:PUB00006666]].</p> <p>Telomerase is not normally expressed in somatic cells and it has been suggested that exogenous TERT may extend the lifespan of, or even immortalise, the cell. However, recent studies have shown that telomerase activity can be induced by a number of oncogenes [[cite:PUB00006624]]. Conversely, the oncogene c-myc can be activated in human TERT immortalised cells [[cite:PUB00006622]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Molecular function | Telomerase RNA reverse transcriptase activity | Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: telomerase reverse transcriptase-like [Glycine max] gi|356555309|ref|XP_003545976.1| | 14 | ||
| – | Telomerase reverse transcriptase [Populus trichocarpa] gi|198075764|gb|ACH81294.1| | 14 | ||
| – | Telomerase reverse transcriptase; TAIR: AT5G16850.1 telomerase reverse transcriptase; Swiss-Prot: sp|Q9SPU7|TERT_ARATH Telomerase reverse transcriptase; TrEMBL-Plants: tr|V7BV12|V7BV12_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0123100 | 2 | ||
| – | Telomerase reverse transcriptase; TAIR: AT5G16850.1 telomerase reverse transcriptase; Swiss-Prot: sp|Q9SPU7|TERT_ARATH Telomerase reverse transcriptase; TrEMBL-Plants: tr|V7BV12|V7BV12_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0123100 | 15 | ||
| – | Telomerase reverse transcriptase; TAIR: AT5G16850.1 telomerase reverse transcriptase; Swiss-Prot: sp|Q9SPU7|TERT_ARATH Telomerase reverse transcriptase; TrEMBL-Plants: tr|V7BV12|V7BV12_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0123100 | 2 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR12066 | PANTHER | 1 | 20.00 |