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IPR022768 is a Fascin-like domain.
<p>This entry represents the fascin-like domain, which is found repeated four times in members of the fascin family. This domain adopts a β-trefoil fold [[cite:PUB00065219]].</p> <p>The fascins are a structurally unique and evolutionarily conserved group of actin cross-linking proteins. Fascins function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles. The cortical structures, which include filopodia, spikes, lamellipodial ribs, oocyte microvilli and the dendrites of dendritic cells, have roles in cell-matrix adhesion, cell interactions and cell migration, whereas the cytoplasmic actin bundles appear to participate in cell architecture [[cite:PUB00012306]]. Dictyostelium hisactophilin, another actin-binding protein, is a submembranous pH sensor that signals slight changes of the H+ concentration to actin by inducing actin polymerisation and binding to microfilaments only at pH values below seven [[cite:PUB00012306]]. Members of this group are histidine rich, typically contain the repeated motif of HHXH [[cite:PUB00012367]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Protein binding, bridging | The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. | ||
| Molecular function | Actin filament binding | Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Glucan 1,3-beta-glucosidase [Medicago truncatula] gi|357463267|ref|XP_003601915.1| | 25 | ||
| – | Glucan 1,3-beta-glucosidase; TAIR: AT4G39170.1 Sec14p-like phosphatidylinositol transfer family protein; Swiss-Prot: sp|B0XN12|EXGA_ASPFC Probable glucan 1,3-beta-glucosidase A; TrEMBL-Plants: tr|V7D1X4|V7D1X4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0090500 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 50.00 |